HIV感染及艾滋病患者的CD4细胞计数、血脂谱和口腔表现
CD4 Cell Counts, Lipid Profile, and Oral Manifestations in HIV-Infected and AIDS Patients.
作者信息
Sridevi Koduri, Malathi Saka, Kv Chalapathi, G Chowdary Nagarjuna, Gayathri M, Chand G Eswar, Nayyar Abhishek Singh
机构信息
Department of Oral Medicine and Radiology, Lenora Institute of Dental Sciences, Rajahmundry, Andhra Pradesh, India.
Department of Oral Medicine and Radiology, Army College of Dental Sciences, Secunderabad, Telangana, India.
出版信息
Front Dent. 2019 Nov-Dec;16(6):436-449. doi: 10.18502/fid.v16i6.3443. Epub 2019 Dec 20.
OBJECTIVES
The present study aimed to evaluate CD4 cell counts, lipid profile, and oral manifestations in human immunodeficiency virus (HIV)-infected and acquired immune deficiency syndrome (AIDS) patients and their correlation with seronegative controls.
MATERIALS AND METHODS
In this cross-sectional, hospital-based study, there were three groups of subjects: group A consisting of 500 healthy patients (controls), group B composed of 500 HIV-infected patients, and group C comprised of 500 AIDS patients based on their CD4 cell counts. CD4 cell counts were assessed using the CyFlow counter. Lipid profile was evaluated with the Erba EM 360 analyzer.
RESULTS
The results were statistically significant for CD4 cell counts (P<0.001). The levels of total cholesterol (TC) and low-density lipoproteins (LDLs) were significantly decreased while triglycerides (TGs) and very-low-density lipoproteins (VLDLs) were significantly increased in AIDS patients compared to the controls and HIV-infected patients. Various results were obtained regarding oral manifestations with different levels of significance.
CONCLUSION
CD4 cell counts, TC, LDLs, TGs, and VLDLs were significantly changed in HIV-infected and AIDS patients compared to the controls.
目的
本研究旨在评估人类免疫缺陷病毒（HIV）感染及获得性免疫缺陷综合征（AIDS）患者的CD4细胞计数、血脂谱和口腔表现，以及它们与血清学阴性对照者的相关性。
材料与方法
在这项基于医院的横断面研究中，有三组受试者：A组由500名健康患者（对照者）组成，B组由500名HIV感染患者组成，C组由500名根据CD4细胞计数划分的AIDS患者组成。使用CyFlow计数器评估CD4细胞计数。用Erba EM 360分析仪评估血脂谱。
结果
CD4细胞计数结果具有统计学意义（P<0.001）。与对照者和HIV感染患者相比，AIDS患者的总胆固醇（TC）和低密度脂蛋白（LDL）水平显著降低，而甘油三酯（TG）和极低密度脂蛋白（VLDL）水平显著升高。关于口腔表现获得了各种具有不同显著水平的结果。
结论
与对照者相比，HIV感染患者和AIDS患者的CD4细胞计数、TC、LDL、TG和VLDL有显著变化。
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