Meloni F, Transi M G, Nigro D, Belli S, Bernardi A, Bottazzi M, Valesini G
IV Clinica Medica Generale e Terapia Medica, Università degli Studi di Roma La Sapienza.
Clin Ter. 1990 Dec 15;135(5):367-72.
Twenty subjects, 17 females and 3 males, mean age 55.9, with Sjögren's syndrome (13 cases: classical or secondary form--7 cases: sicca syndrome) were submitted to biopsy of the minor salivary glands of the lower lip. The histopathological findings from the salivary glands and the clinical aspects of each patient were separately evaluated, in order to find a possible connection between the degree of glandular impairment and the severity of the disease. As a result of their findings, the authors conclude that the biopsy of the salivary glands, while constituting an important element for diagnosis, cannot be considered a determining factor for making a prognosis, or for therapy, because of the extreme polymorphism in the histopathological findings, and for the relative nature of the respondents with the severity of the clinical aspects.
20名受试者,17名女性和3名男性,平均年龄55.9岁,患有干燥综合征(13例:典型或继发性形式——7例:干燥综合征),接受了下唇小唾液腺活检。对唾液腺的组织病理学发现和每位患者的临床情况进行了单独评估,以寻找腺体损伤程度与疾病严重程度之间的可能联系。根据他们的发现,作者得出结论,唾液腺活检虽然是诊断的重要因素,但由于组织病理学发现的极端多态性以及与临床情况严重程度相关的相对性质,不能被视为预后或治疗的决定性因素。