Division of Diabetes and Endocrinology, Department of Internal Medicine, Jikei University Daisan Hospital, Tokyo, Japan.
Diabetes Technol Ther. 2011 Jul;13(7):699-703. doi: 10.1089/dia.2011.0025. Epub 2011 Apr 19.
This study was performed to examine the efficacy of sitagliptin, a dipeptidyl peptidase-4 inhibitor, in Japanese patients with type 2 diabetes using continuous glucose monitoring (CGM) of 24-h glycemic changes.
The study was a prospective open-label pilot study in patients with type 2 diabetes who were admitted to our hospital and treated with sitagliptin alone or concomitantly with another oral hypoglycemic drug. CGM was performed for 2 days before sitagliptin administration and for another 2 days after administration. The average 24-h blood glucose level, SD of the 24-h blood glucose level, 24-h glycemic fluctuation range, mean amplitude of glycemic excursions (MAGE), and hyperglycemic and hypoglycemic time periods were compared before and after administration.
Sitagliptin administration alone and with a concomitant drug decreased the average 24-h blood glucose level, SD of the 24-h blood glucose level, 24-h glycemic fluctuation range, MAGE, and hyperglycemic time, compared with these parameters before administration. There were significant correlations between the average 24-h blood glucose level before administration and the decrease in the average 24-h blood glucose level after administration and between MAGE before administration and the decrease in MAGE after administration.
Sitagliptin decreased the average glycemic level and also improved 24-h glycemic fluctuation, including postprandial hyperglycemia.
本研究旨在使用 24 小时血糖监测（CGM）检查二肽基肽酶-4 抑制剂西他列汀对日本 2 型糖尿病患者的疗效。
这是一项在我院住院并单独使用或联合其他口服降糖药物治疗的 2 型糖尿病患者中进行的前瞻性开放标签试点研究。在使用西他列汀之前和之后进行了 2 天的 CGM，在使用西他列汀之前和之后各进行了 2 天。比较了给药前后的 24 小时平均血糖水平、24 小时血糖水平标准差、24 小时血糖波动范围、平均血糖波动幅度（MAGE）以及高血糖和低血糖时间段。
与给药前相比，单独使用西他列汀和联合药物可降低 24 小时平均血糖水平、24 小时血糖水平标准差、24 小时血糖波动范围、MAGE 和高血糖时间。给药前的 24 小时平均血糖水平与给药后 24 小时平均血糖水平的降低呈显著相关，而给药前的 MAGE 与给药后 MAGE 的降低呈显著相关。
西他列汀降低了平均血糖水平，还改善了 24 小时血糖波动，包括餐后高血糖。
