Littley M D, Pollock A, Kane J, Shalet S M
Department of Endocrinology, Christie Hospital, Withington, Manchester, UK.
Ann Clin Biochem. 1990 Nov;27 ( Pt 6):557-61. doi: 10.1177/000456329002700606.
The concentration of dehydroepiandrosterone sulphate (DHEAS) was measured in the plasma of 104 patients aged 16-78 years (48 men) undergoing routine assessment of anterior pituitary reserve. A fasting plasma sample was collected at 0900 h on the same day that either an insulin tolerance test or a glucagon stimulation test was performed. Serum cortisol, DHEAS and prolactin were measured by radioimmunoassay. DHEAS levels between 0.5 and 14 nmol/L were significantly but negatively correlated with age but there was no significant correlation with basal cortisol, maximum stimulated cortisol, the increment in cortisol or basal prolactin. The correlation of DHEAS with age was also observed when results for women were analysed separately but this did not hold for men. For male and female results separately, there was again no correlation of basal DHEAS with basal cortisol, maximum stimulated cortisol, increment of cortisol or basal prolactin. The age and sex related reference range and other factors affecting basal DHEAS concentration make it a cumbersome and unreliable measure of hypothalamic-pituitary-adrenal axis reserve.
对104名年龄在16 - 78岁（48名男性）接受垂体前叶储备常规评估的患者的血浆进行硫酸脱氢表雄酮（DHEAS）浓度测定。在进行胰岛素耐量试验或胰高血糖素刺激试验的同一天上午9点采集空腹血浆样本。采用放射免疫分析法测定血清皮质醇、DHEAS和催乳素。DHEAS水平在0.5至14 nmol/L之间与年龄呈显著负相关，但与基础皮质醇、最大刺激皮质醇、皮质醇增量或基础催乳素无显著相关性。单独分析女性结果时也观察到DHEAS与年龄的相关性，但男性情况并非如此。分别对男性和女性结果进行分析，基础DHEAS与基础皮质醇、最大刺激皮质醇、皮质醇增量或基础催乳素同样无相关性。年龄和性别相关的参考范围以及影响基础DHEAS浓度的其他因素，使得它成为一种繁琐且不可靠的下丘脑 - 垂体 - 肾上腺轴储备指标。
