Komajda M, Klimczak K, Evans J, Boutin B, Brackman F, Guez D, Grosgogeat Y
Hôpital Pitié-Salpêtrière, Paris.
Arch Mal Coeur Vaiss. 1990 Dec;83 Spec No 4:45-50.
Left ventricular hypertrophy is a major and independent cardiovascular risk factor in hypertension. The effects of a diuretic, indapamide, on the regression of left ventricular hypertrophy were studied in a group of 9 patients with mild hypertension treated in an open therapeutic trial over a 12 month period. At the end of the trial, the left ventricular mass index decreased significantly from 172 +/- 11 to 147 +/- 11 g/m2 (p less than 0.001). Therefore, in contrast to the other diuretics which have been studied, indapamide seems able to induce regression of the left ventricular hypertrophy complicating hypertension.
左心室肥厚是高血压中一个主要的独立心血管危险因素。在一项开放治疗试验中，对一组9例轻度高血压患者进行了为期12个月的研究，观察了利尿剂吲达帕胺对左心室肥厚消退的影响。试验结束时，左心室质量指数从172±11显著降至147±11 g/m2（p<0.001）。因此，与其他已研究的利尿剂不同，吲达帕胺似乎能够使并发于高血压的左心室肥厚消退。
