Reilly C D, Panday V, Lazos V, Mittelstaedt B R
Wilford Hall, Warfighter Refractive Surgery Center, San Antonio, TX, USA.
Nepal J Ophthalmol. 2010 Jul-Dec;2(2):97-104. doi: 10.3126/nepjoph.v2i2.3715.
The field of refractive surgery continues to evolve amid continued concerns as to which surgical technique minimizes the risk of inducing ectasia.
To compare clinical outcomes between PRK, LASEK and Epi-LASIK in moderately to highly myopic eyes (-4.00 D to -8.00 D).
A retrospective chart review of 100 PRK eyes, 100 LASEK eyes (with alcohol) and 97 Epi-LASIK eyes was performed. Post-operative pain, uncorrected visual acuity, and corneal haze data was recorded and analyzed at post-op days 1, 4 and 7 and at post-op months 1, 3, 6 and 12.
In all groups surgical corrections ranged from -4.00 D to -8.00 D. There was less pain associated with the epi-LASIK procedure especially early (post-op days 1 and 4). Visual recovery was superior within the PRK group during the first post-operative week but by post-op week 4 all three were equal. Haze scores were similar but a trend for less haze was demonstrated with epi-LASIK at 6 and 12 months.
Epi-LASIK has a slight advantage over PRK and LASEK early on in the post-op course with regards to pain. Visual recovery is similar by 4 weeks and is better with PRK early. In addition, epi-LASIK trends toward less significant haze.
在对于哪种手术技术能将诱发角膜扩张风险降至最低仍持续存在担忧的情况下，屈光手术领域不断发展。
比较准分子激光角膜切削术（PRK）、准分子激光上皮瓣下角膜磨镶术（LASEK）和机械法-准分子激光上皮瓣下角膜磨镶术（Epi-LASIK）在中度至高度近视（-4.00 D至-8.00 D）眼中的临床结果。
对100只接受PRK手术的眼睛、100只接受LASEK手术（使用酒精）的眼睛和97只接受Epi-LASIK手术的眼睛进行回顾性病历分析。记录并分析术后第1天、第4天和第7天以及术后1个月、3个月、6个月和12个月时的术后疼痛、未矫正视力和角膜混浊数据。
所有组的手术矫正范围均为-4.00 D至-8.00 D。Epi-LASIK手术相关的疼痛较少，尤其是在早期（术后第1天和第4天）。在术后第一周内，PRK组的视力恢复较好，但到术后第4周时，三者恢复情况相同。角膜混浊评分相似，但在术后6个月和12个月时，Epi-LASIK显示出角膜混浊较轻的趋势。
在术后早期，就疼痛方面而言，Epi-LASIK比PRK和LASEK略有优势。4周时视力恢复情况相似，早期PRK恢复更好。此外，Epi-LASIK有角膜混浊较轻的趋势。
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