Vyhnánek F, Lochmann O, Procházka M, Vojtisek O, Absolonová V
Chirurgická klinika lékarské fakulty hygienické Univerzity Karlovy, Praha.
Cesk Epidemiol Mikrobiol Imunol. 1990 Jul;39(4):193-200.
The author investigated the antimicrobial action of noxythioline, prepared by the Research Institute for Pharmacy and Biochemistry in Prague, in laboratory work as well as under clinical conditions. In the laboratory investigation the author assessed the minimal inhibitory concentration against aerobic and anaerobic bacteria within the range of 512-2048 mg/l, which is sufficient from the aspect of the noxythioline concentration (2.5%) used in clinical work. In the clinical part of the investigation noxythioline was administered to 58 patients hospitalized at the surgical clinic of the Medical Faculty of Hygiene in Prague in 1988-1989. In 13 patients it was used prophylactically in planned or acute intraabdominal operations. Therapeutically it was used in 45 patients operated mostly on account of intraabdominal diseases complicated by peritonitis or an abscess. Preliminary results confirmed the satisfactory effect of noxythioline VUFB which is comparable with Noxyflex S of Geistlich Co.
作者在实验室研究以及临床条件下，对布拉格药学与生物化学研究所制备的硝噻唑啉的抗菌作用进行了研究。在实验室研究中，作者评估了其对需氧菌和厌氧菌的最低抑菌浓度，范围在512 - 2048毫克/升，从临床工作中使用的硝噻唑啉浓度（2.5%）方面来看，这一浓度已足够。在调查的临床部分，1988 - 1989年期间，硝噻唑啉被给予了布拉格卫生医学院外科诊所收治的58名患者。在13名患者中，它被用于计划性或急性腹部手术的预防性治疗。在45名患者中，它被用于治疗，这些患者大多因腹部疾病并发腹膜炎或脓肿而接受手术。初步结果证实了硝噻唑啉VUFB的满意效果，其与 Geistlich 公司的 Noxyflex S 相当。
