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北京老龄化纵向研究中从中年后期开始的脆弱性和生存分析。

Analysis of frailty and survival from late middle age in the Beijing Longitudinal Study of Aging.

机构信息

Beijing Institute of Geriatrics, Beijing Hospital, Ministry of Health, Beijing, China.

出版信息

BMC Geriatr. 2011 Apr 20;11:17. doi: 10.1186/1471-2318-11-17.

Abstract

BACKGROUND

Frailty in individuals can be operationalized as the accumulation of health deficits, for which several trends have been observed in Western countries. Less is known about deficit accumulation in China, the country with the world's largest number of older adults.

METHODS

This study analyzed data from the Beijing Longitudinal Study of Aging, to evaluate the relationship between age and deficit accumulation in men and women and to evaluate the impact of frailty on mortality. Community dwelling people aged 55+ years at baseline (n = 3275) were followed every two to three years between 1992 and 2000, during which time 36% died. A Frailty Index was constructed using 35 deficits, drawn from a range of health problems, including symptoms, disabilities, disease, and psychological difficulties.

RESULTS

Most deficits increased the eight-year risk of death and were more lethal in men than in women, although women had a higher mean level of frailty (Frailty Index = 0.11 ± 0.10 for men, 0.14 ± 0.12 for women). The Frailty Index increased exponentially with age, with a similar rate in men and women (0.038 vs. 0.039; r > 0.949, P < 0.01). A dose-response relationship was observed as frailty increased.

CONCLUSIONS

A Frailty Index employed in a Chinese sample, showed properties comparable with Western data, but deficit accumulation appeared to be more lethal than in the West.

摘要

背景

个体的虚弱可以通过健康缺陷的积累来操作化,在西方国家已经观察到了几种趋势。对于中国这个拥有世界上最多老年人的国家,关于缺陷积累的了解较少。

方法

本研究分析了来自北京老龄化纵向研究的数据,以评估年龄与男性和女性缺陷积累之间的关系,并评估虚弱对死亡率的影响。在基线时年龄为 55 岁及以上的社区居住者(n=3275)在 1992 年至 2000 年间每两到三年接受一次随访,在此期间有 36%的人死亡。使用 35 种缺陷构建了虚弱指数,这些缺陷来自一系列健康问题,包括症状、残疾、疾病和心理困难。

结果

大多数缺陷增加了八年的死亡风险,而且男性比女性更致命,尽管女性的虚弱程度更高(男性的虚弱指数=0.11±0.10,女性的虚弱指数=0.14±0.12)。虚弱指数随年龄呈指数增长,男性和女性的增长率相似(0.038 对 0.039;r>0.949,P<0.01)。随着虚弱程度的增加,观察到了剂量反应关系。

结论

在中国样本中使用的虚弱指数表现出与西方数据相当的特性,但缺陷积累似乎比西方更致命。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ba1/3239314/c350ac3329b7/1471-2318-11-17-1.jpg

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