Division of Chemical and Biomolecular Engineering, College of Engineering, Nanyang Technological University, 16 Nanyang Drive, Singapore 637722, Singapore.
J Chromatogr A. 2011 Jun 3;1218(22):3496-501. doi: 10.1016/j.chroma.2011.03.071. Epub 2011 Apr 4.
Cyclodextrin and its derivatives are widely used as selectors of chiral stationary phases (CSPs) for high performance liquid chromatography (HPLC) due to their unique molecular structure and resolution capability. Three mono(6(A)-N-(ω-alkenylamino)-6(A)-deoxy)perphenylcarbamoylated β-cyclodextrin (PICD) based CSPs with different length spacers have been prepared, with their enantioseparation abilities evaluated with 10 model racemates including aromatic alcohols, flavanone compounds, amine and non-protolytic compounds under normal-phase conditions. The effect of spacer length and surface loading on the enantioseparation performance of CSPs is investigated herewith. The results indicate that higher surface loading 6C-PICD displays the best enantioselectivities towards selected racemates under normal-phase conditions.
环糊精及其衍生物由于其独特的分子结构和拆分能力，被广泛用作高效液相色谱（HPLC）手性固定相（CSP）的选择剂。本文制备了三种不同长度间隔基的单（6(A)-N-(ω-烯基氨基)-6(A)-去氧）对苯甲酰基化β-环糊精（PICD）手性固定相，在正相条件下，用 10 种模型对映体（包括芳香醇、黄烷酮化合物、胺和非质子解析化合物）评价了它们的对映体分离能力。本文研究了间隔基长度和表面负载对 CSP 对映体分离性能的影响。结果表明，在正相条件下，较高的表面负载 6C-PICD 对所选对映体具有最佳的对映选择性。
