Department of Signals and Systems, Chalmers University of Technology, Gothenburg 41296, Sweden.
IEEE Trans Biomed Eng. 2011 Jul;58(7):2072-82. doi: 10.1109/TBME.2011.2142415. Epub 2011 Apr 15.
Myogenic autoregulation of cerebral blood flow is one of the mechanisms affecting cerebral hemodynamics. Short or long-lasting changes in intracranial pressure (ICP) are believed to reveal the responses of the cerebral system to myogenic stimuli. Through the incorporation of a theoretical model into the experimental measurements of cerebrovascular distensibility and compliance in patients with traumatic brain injury (TBI), the current study is an attempt to explain ICP dynamics in either presence or absence of cerebral autoregulation. The pulse wave velocity and transfer function between arterial blood pressure and ICP were utilized as the major tools to reflect variations in the mechanical properties of distant cerebral artries/arteriols. The results imply that different states of cerebral autoregulation and associated regimes within the cerebrovascular system can lead to different types of interrelationship between the slow variations of ICP, cerebral arterial distensibility, and compliance. Consequently, each of these classes may require different types of treatment on patients with TBI.
脑血流的肌源性自身调节是影响脑血流动力学的机制之一。人们认为，颅内压（ICP）的短期或长期变化可以揭示大脑系统对肌源性刺激的反应。本研究通过将理论模型纳入创伤性脑损伤（TBI）患者的脑血管可扩张性和顺应性的实验测量中，试图解释在存在或不存在脑自身调节的情况下 ICP 动力学。脉搏波速度和动脉血压与 ICP 之间的传递函数被用作反映远端脑动脉/小动脉机械特性变化的主要工具。结果表明，不同的脑自身调节状态和脑血管系统内的相关状态可能导致 ICP、脑动脉可扩张性和顺应性的缓慢变化之间存在不同类型的相互关系。因此，TBI 患者的每一类可能需要不同类型的治疗。
