周围 GABA 激活的紧张性抑制通过去极化分流机制增强听觉吻合检测。
Ambient GABA-activated tonic inhibition sharpens auditory coincidence detection via a depolarizing shunting mechanism.
机构信息
Department of Anatomy and Neurobiology, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio 44272, USA.
出版信息
J Neurosci. 2011 Apr 20;31(16):6121-31. doi: 10.1523/JNEUROSCI.4733-10.2011.
Abstract
Tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABA(A)Rs) has emerged as a novel form of neural inhibition in the CNS. However, little is known about its presence and function in the auditory system. Using whole-cell recordings in brain slices, we identified a tonic current mediated by GABA(A)Rs containing the δ subunit in middle/high-characteristic-frequency neurons of the chicken nucleus laminaris, the first interaural time difference encoder that computes information for sound localization. This tonic conductance was activated by ambient concentrations of GABA released from synaptic vesicles. Furthermore, pharmacological manipulations of the conductance demonstrated its essential role in coincidence detection. Remarkably, this depolarizing tonic conductance was strongly inhibitory primarily because of its shunting effect. These results demonstrate a novel role for tonic inhibition in central auditory information processing.
摘要
突触外 GABA(A) 受体（GABA(A)Rs）介导的紧张性抑制作用已成为中枢神经系统中一种新的神经抑制形式。然而，其在听觉系统中的存在和功能知之甚少。通过在脑切片上进行全细胞膜片钳记录，我们在鸡核层状体的中/高频特征频率神经元中鉴定出一种由δ亚基组成的 GABA(A)R 介导的紧张性电流，该神经元是第一个用于声音定位的计算双耳时差信息的听觉中间神经元。这种紧张性电导被来自突触小泡的 GABA 的环境浓度激活。此外，对电导的药理学操作表明其在检测偶合方面的重要作用。值得注意的是，这种去极化紧张性电导具有很强的抑制作用，主要是由于其分流效应。这些结果表明紧张性抑制在中枢听觉信息处理中具有新的作用。
相似文献
1
Ambient GABA-activated tonic inhibition sharpens auditory coincidence detection via a depolarizing shunting mechanism.周围 GABA 激活的紧张性抑制通过去极化分流机制增强听觉吻合检测。
J Neurosci. 2011 Apr 20;31(16):6121-31. doi: 10.1523/JNEUROSCI.4733-10.2011.
2
Reduced GABA(A) receptor-mediated tonic inhibition in aged rat auditory thalamus.老年大鼠听觉丘脑 GABA(A) 受体介导的紧张性抑制减弱。
J Neurosci. 2013 Jan 16;33(3):1218-27a. doi: 10.1523/JNEUROSCI.3277-12.2013.
3
Heterogeneous kinetics and pharmacology of synaptic inhibition in the chick auditory brainstem.雏鸡听觉脑干中突触抑制的异质性动力学和药理学
J Neurosci. 2009 Jul 29;29(30):9625-34. doi: 10.1523/JNEUROSCI.0103-09.2009.
4
Control of a depolarizing GABAergic input in an auditory coincidence detection circuit.听觉重合检测回路中去极化GABA能输入的调控
J Neurophysiol. 2009 Sep;102(3):1672-83. doi: 10.1152/jn.00419.2009. Epub 2009 Jul 1.
5
The cooperation of sustained and phasic inhibitions increases the contrast of ITD-tuning in low-frequency neurons of the chick nucleus laminaris.持续和相位抑制的协同作用增加了小鸡顶盖核低频神经元对 ITD 调谐的对比度。
J Neurosci. 2013 Feb 27;33(9):3927-38. doi: 10.1523/JNEUROSCI.2377-12.2013.
6
Robust tonic GABA currents can inhibit cell firing in mouse newborn neocortical pyramidal cells.在新生小鼠大脑皮层锥体神经元中，强而稳定的抑制性γ-氨基丁酸（GABA）电流可抑制神经元放电。
Eur J Neurosci. 2010 Oct;32(8):1310-8. doi: 10.1111/j.1460-9568.2010.07373.x. Epub 2010 Sep 16.
7
Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus.突触外 GABA(A) 受体将躯体感觉丘脑的突触前活动与突触后抑制联系起来。
J Neurosci. 2013 Sep 11;33(37):14850-68. doi: 10.1523/JNEUROSCI.1174-13.2013.
8
Dual GABAA receptor-mediated inhibition in rat presympathetic paraventricular nucleus neurons.双GABAA受体介导的大鼠交感神经节前室旁核神经元抑制作用
J Physiol. 2007 Jul 15;582(Pt 2):539-51. doi: 10.1113/jphysiol.2007.133223. Epub 2007 May 10.
9
Profound desensitization by ambient GABA limits activation of δ-containing GABAA receptors during spillover.环境 GABA 的深度脱敏作用限制了溢出时 δ 包含的 GABAA 受体的激活。
J Neurosci. 2011 Jan 12;31(2):753-63. doi: 10.1523/JNEUROSCI.2996-10.2011.
10
A developmental switch to GABAergic inhibition dependent on increases in Kv1-type K+ currents.一种依赖于Kv1型钾电流增加的向γ-氨基丁酸能抑制的发育转变。
J Neurosci. 2007 Feb 21;27(8):2112-23. doi: 10.1523/JNEUROSCI.5266-06.2007.
引用本文的文献
1
Established and emerging GABA receptor pharmacotherapy for epilepsy.用于癫痫的已确立和新兴的γ-氨基丁酸（GABA）受体药物治疗
Front Pharmacol. 2024 Feb 21;15:1341472. doi: 10.3389/fphar.2024.1341472. eCollection 2024.
2
GABA tone regulation and its cognitive functions in the brain.GABA 调tone 及其在大脑中的认知功能。
Nat Rev Neurosci. 2023 Sep;24(9):523-539. doi: 10.1038/s41583-023-00724-7. Epub 2023 Jul 26.
3
Focusing on the Emerging Role of Kainate Receptors in the Dorsal Cochlear Nucleus (DCN) and Cerebellum.关注红藻氨酸受体在耳蜗背核（DCN）和小脑中的新兴作用。
Int J Mol Sci. 2023 Jan 15;24(2):1718. doi: 10.3390/ijms24021718.
4
Tonotopic differentiation of presynaptic neurotransmitter-releasing machinery in the auditory brainstem during the prehearing period and its selective deficits in Fmr1 knockout mice.在听觉脑干的听力前期间，突触前神经递质释放机制的音调分化及其在 Fmr1 敲除小鼠中的选择性缺陷。
J Comp Neurol. 2022 Dec;530(18):3248-3269. doi: 10.1002/cne.25406. Epub 2022 Sep 6.
5
Cellular Strategies for Frequency-Dependent Computation of Interaural Time Difference.用于双耳时间差频率依赖性计算的细胞策略
Front Synaptic Neurosci. 2022 May 6;14:891740. doi: 10.3389/fnsyn.2022.891740. eCollection 2022.
6
Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem.代谢型谷氨酸受体在听觉脑干声音定位回路中的调制作用。
Front Neural Circuits. 2020 Nov 5;14:599600. doi: 10.3389/fncir.2020.599600. eCollection 2020.
7
Extracellular GABA waves regulate coincidence detection in excitatory circuits.细胞外 GABA 波调节兴奋性回路中的契合检测。
J Physiol. 2020 Sep;598(18):4047-4062. doi: 10.1113/JP279744. Epub 2020 Aug 4.
8
The Functional Role of Spontaneously Opening GABA Receptors in Neural Transmission.自发开放的γ-氨基丁酸受体在神经传递中的功能作用
Front Mol Neurosci. 2019 Mar 28;12:72. doi: 10.3389/fnmol.2019.00072. eCollection 2019.
9
Anatomy and Physiology of Metabotropic Glutamate Receptors in Mammalian and Avian Auditory System.哺乳动物和鸟类听觉系统中代谢型谷氨酸受体的解剖学与生理学
HSOA Trends Anat Physiol. 2018;1. doi: 10.24966/TAP-7752/100001. Epub 2018 Feb 9.
10
GABA is a modulator, rather than a classical transmitter, in the medial nucleus of the trapezoid body-lateral superior olive sound localization circuit.GABA 在梯形体内侧核-外侧上橄榄核声音定位回路中是一种调制物，而不是经典的递质。
J Physiol. 2019 Apr;597(8):2269-2295. doi: 10.1113/JP277566. Epub 2019 Mar 12.
本文引用的文献
1
Channel-mediated tonic GABA release from glia.缝隙连接介导热敏型 GABA 从神经胶质细胞中的释放。
Science. 2010 Nov 5;330(6005):790-6. doi: 10.1126/science.1184334. Epub 2010 Sep 23.
2
Dynamic spike thresholds during synaptic integration preserve and enhance temporal response properties in the avian cochlear nucleus.在突触整合过程中，动态峰电位阈值可维持并增强禽类耳蜗核的时间响应特性。
J Neurosci. 2010 Sep 8;30(36):12063-74. doi: 10.1523/JNEUROSCI.1840-10.2010.
3
Control of submillisecond synaptic timing in binaural coincidence detectors by K(v)1 channels.通过 K(v)1 通道控制双耳吻合检测器中的亚毫秒级突触定时。
Nat Neurosci. 2010 May;13(5):601-9. doi: 10.1038/nn.2530. Epub 2010 Apr 4.
4
Presynaptic GABAA receptors enhance transmission and LTP induction at hippocampal mossy fiber synapses.突触前 GABAA 受体增强海马苔藓纤维突触的传递和 LTP 诱导。
Nat Neurosci. 2010 Apr;13(4):431-8. doi: 10.1038/nn.2512. Epub 2010 Mar 21.
5
A critical role for alpha4betadelta GABAA receptors in shaping learning deficits at puberty in mice.alpha4betadelta GABAA 受体在塑造青春期小鼠学习缺陷方面的关键作用。
Science. 2010 Mar 19;327(5972):1515-8. doi: 10.1126/science.1184245.
6
Mechanisms for adjusting interaural time differences to achieve binaural coincidence detection.调整耳间时间差以实现双耳同时检测的机制。
J Neurosci. 2010 Jan 6;30(1):70-80. doi: 10.1523/JNEUROSCI.3464-09.2010.
7
Control of hippocampal gamma oscillation frequency by tonic inhibition and excitation of interneurons.通过中间神经元的紧张性抑制和兴奋来控制海马γ振荡频率。
Nat Neurosci. 2010 Feb;13(2):205-12. doi: 10.1038/nn.2464. Epub 2009 Dec 20.
8
Extrasynaptic GABAA receptors: form, pharmacology, and function.突触外GABAA受体：形态、药理学及功能
J Neurosci. 2009 Oct 14;29(41):12757-63. doi: 10.1523/JNEUROSCI.3340-09.2009.
9
Regulation of glutamatergic and GABAergic neurotransmission in the chick nucleus laminaris: role of N-type calcium channels.调节雏鸡核层状的谷氨酸能和 GABA 能神经传递：N 型钙通道的作用。
Neuroscience. 2009 Dec 15;164(3):1009-19. doi: 10.1016/j.neuroscience.2009.09.013. Epub 2009 Sep 12.
10
Control of a depolarizing GABAergic input in an auditory coincidence detection circuit.听觉重合检测回路中去极化GABA能输入的调控
J Neurophysiol. 2009 Sep;102(3):1672-83. doi: 10.1152/jn.00419.2009. Epub 2009 Jul 1.
Zotero 插件