Department of Biomedical Engineering, University of Houston, Houston, TX, USA.
J Lipid Res. 2011 Jul;52(7):1429-34. doi: 10.1194/jlr.D015255. Epub 2011 Apr 20.
Atherosclerosis is an inflammatory process occurring in arterial tissue, involving the subintimal accumulation of LDL. Measurement of the rate at which LDL and other lipoproteins, such as HDL and VLDL, enter and exit the tissue can provide insight into the mechanisms involved in the development of atherosclerotic lesions. Permeation of VLDL, LDL, HDL, and glucose was measured for both normal and atherosclerotic human carotid endarterectomy tissues (CEA) at 20°C and 37°C using optical coherence tomography (OCT). The rates for LDL permeation through normal CEA tissue were (3.16 ± 0.37) × 10(-5) cm/s at 20°C and (4.77 ± 0.48) × 10(-5) cm/s at 37°C, significantly greater (P < 0.05) than the rates for atherosclerotic CEA tissue at these temperatures [(1.97 ± 0.34) × 10(-5) cm/s at 20°C and (2.01 ± 0.23) × 10(-5) cm/s at 37°C]. This study effectively used OCT to measure the rates at which naturally occurring lipoproteins enter both normal and diseased carotid intimal tissue.
动脉粥样硬化是一种发生在动脉组织中的炎症过程，涉及 LDL 的内膜下积累。测量 LDL 和其他脂蛋白（如 HDL 和 VLDL）进入和离开组织的速度，可以深入了解动脉粥样硬化病变发展过程中的机制。使用光学相干断层扫描（OCT）在 20°C 和 37°C 下测量正常和动脉粥样硬化人类颈动脉内膜切除术（CEA）组织中 VLDL、LDL、HDL 和葡萄糖的渗透速率。在 20°C 时，正常 CEA 组织中 LDL 渗透的速率为（3.16 ± 0.37）×10（-5）cm/s，在 37°C 时为（4.77 ± 0.48）×10（-5）cm/s，明显高于这些温度下动脉粥样硬化 CEA 组织的速率[在 20°C 时为（1.97 ± 0.34）×10（-5）cm/s，在 37°C 时为（2.01 ± 0.23）×10（-5）cm/s]。本研究有效地使用 OCT 测量了天然存在的脂蛋白进入正常和患病颈动脉内膜组织的速度。
