Department of Medicine, University of British Columbia Hospital Vancouver, BC, Canada.
Anticancer Res. 2011 Apr;31(4):1249-58.
Stem cells have recently received a great deal of attention for their clinical and therapeutic potential to treat human disease and disorders. For instance, neural stem cells expressing a suicide gene which can concert prodrugs to their active metabolites may have great tropic and therapeutic potential for brain tumors, i.e., medulloblastoma and glioma. We are currently interested in therapeutic potential of these genetically engineered stem cells (GESTECs) to selectively target invasive tumors, i.e. ovarian, endometrial, breast, and lung cancer which can have a great impact on human and animal health. Thus, in this review we summarize the therapeutic potential of GESTEC, developed by us, and the putative mechanism(s) underlying their therapeutic and tropic potential in expressing suicide genes which can convert prodrugs to their active metabolites and in selectively targeting invasive tumors.
干细胞因其在治疗人类疾病和障碍方面的临床和治疗潜力而受到广泛关注。例如，表达自杀基因的神经干细胞可以将前药转化为其活性代谢物，这对于脑肿瘤，如髓母细胞瘤和神经胶质瘤，具有很大的趋化和治疗潜力。我们目前对这些基因工程干细胞（GESTEC）的治疗潜力感兴趣，这些干细胞可以选择性地针对侵袭性肿瘤，如卵巢癌、子宫内膜癌、乳腺癌和肺癌，这对人类和动物的健康有重大影响。因此，在这篇综述中，我们总结了我们开发的 GESTEC 的治疗潜力，以及它们在表达自杀基因方面的治疗和趋化潜力的潜在机制，这些自杀基因可以将前药转化为其活性代谢物，并选择性地针对侵袭性肿瘤。
