2nd Department of Internal Medicine, Medical School, University of Athens, Athens, Greece.
Anticancer Res. 2011 Apr;31(4):1467-9.
We describe here the rare coexistence, at the time of diagnosis, of a myeloproliferative neoplasm (MPN) and non-Hodgkin's lymphoma (NHL) in a 74-year-old patient who presented with thrombocytosis and signs of portal hypertension on physical examination. Abdominal computed tomography scan demonstrated extensive portal vein system thrombosis. Secondary causes of thrombocytosis were excluded. JAK2 V617F mutation was present in the peripheral blood, while bone marrow biopsy revealed marginal zone B-cell lymphoma. Molecular analysis failed to detect BCR-ABL rearrangement in peripheral blood cells. Simultaneous occurrence of MPN and NHL was diagnosed. This case may be of interest not only due to the rare coexistence of PMN and NHL, but also because of the undetermined clinical significance of JAK2 mutation in this subset of patients.
我们在这里描述了一种罕见的情况，即在一名 74 岁的患者中，在诊断时同时存在骨髓增殖性肿瘤（MPN）和非霍奇金淋巴瘤（NHL），该患者表现为血小板增多和体检时门静脉高压的迹象。腹部计算机断层扫描显示广泛的门静脉系统血栓形成。排除了血小板增多的继发原因。外周血中存在 JAK2 V617F 突变，而骨髓活检显示边缘区 B 细胞淋巴瘤。分子分析未能在外周血细胞中检测到 BCR-ABL 重排。诊断为同时发生 MPN 和 NHL。这种情况不仅可能因为 MPN 和 NHL 的罕见共存而引起关注，还可能因为 JAK2 突变在这组患者中的临床意义尚未确定。
