Korthals J K, Korthals M A
James A. Haley Veterans Hospital, University of South Florida College of Medicine, Tampa 33612.
J Neurol Sci. 1990 Nov;99(2-3):147-52. doi: 10.1016/0022-510x(90)90151-c.
The severity of necrotic muscle and nerve lesions in the ischemic hind limbs of diabetic and nondiabetic rats was compared. Chronic limb ischemia was induced by repetitive, daily for up to 8 weeks, intraperitoneal injections of serotonin in rats with ligated right femoral artery. Light microscopic examination and lesion severity grading was performed on sections taken from several right hind limb muscles and the right tibial nerve. Overall, muscle was less damaged in diabetic than in nondiabetic rats. However, muscle was damaged more than nerve in all but diabetic rats with severe chronic ischemia. Muscle vulnerability to ischemic damage is decreased in diabetes, presumably due to abundance of glucose and other energy substrates which can be utilized during ischemia.
比较了糖尿病大鼠和非糖尿病大鼠缺血后肢坏死性肌肉和神经损伤的严重程度。通过对结扎右股动脉的大鼠每天重复腹腔注射血清素长达8周来诱导慢性肢体缺血。对取自右侧后肢几块肌肉和右胫神经的切片进行光学显微镜检查和损伤严重程度分级。总体而言，糖尿病大鼠的肌肉损伤程度低于非糖尿病大鼠。然而，除了患有严重慢性缺血的糖尿病大鼠外，所有大鼠的肌肉损伤都比神经损伤更严重。糖尿病状态下肌肉对缺血损伤的易感性降低，这可能是由于缺血期间可利用的葡萄糖和其他能量底物丰富。
