Vidaeff Alex C, Ramin Susan M
Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Clin Obstet Gynecol. 2011 Jun;54(2):337-43. doi: 10.1097/GRF.0b013e318217d85b.
Preterm premature rupture of membranes (PPROM) is an obstetrical complication associated with high neonatal morbidity and mortality. The current management of PPROM focuses on neonatal benefit and includes the ancillary use of corticosteroids for fetal maturation. The purpose of this work was to provide a comprehensive and unbiased review of the available literature on prenatal administration of corticosteroids in conditions of PPROM, and to address the rationale and the relevant supporting evidence for this practice. We conclude that the cumulative level I evidence indicates a definite beneficial effect of corticosteroids in conditions of PPROM.
早产胎膜早破（PPROM）是一种与新生儿高发病率和死亡率相关的产科并发症。目前对PPROM的管理侧重于新生儿获益，包括辅助使用皮质类固醇促进胎儿成熟。这项工作的目的是对PPROM情况下产前使用皮质类固醇的现有文献进行全面且无偏见的综述，并阐述这种做法的基本原理和相关支持证据。我们得出结论，累积的I级证据表明皮质类固醇在PPROM情况下具有明确的有益作用。
