平衡力量：机械转导的建筑控制。
Balancing forces: architectural control of mechanotransduction.
机构信息
Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco (UCSF), CA, USA.
出版信息
Nat Rev Mol Cell Biol. 2011 May;12(5):308-19. doi: 10.1038/nrm3112.
Abstract
All cells exist within the context of a three-dimensional microenvironment in which they are exposed to mechanical and physical cues. These cues can be disrupted through perturbations to mechanotransduction, from the nanoscale-level to the tissue-level, which compromises tensional homeostasis to promote pathologies such as cardiovascular disease and cancer. The mechanisms of such perturbations suggest that a complex interplay exists between the extracellular microenvironment and cellular function. Furthermore, sustained disruptions in tensional homeostasis can be caused by alterations in the extracellular matrix, allowing it to serve as a mechanically based memory-storage device that can perpetuate a disease or restore normal tissue behaviour.
摘要
所有细胞都存在于三维微环境中，在这个环境中，它们会受到机械和物理线索的影响。这些线索可以通过从纳米级到组织级的机械转导的干扰而被破坏，这会破坏张力平衡，促进心血管疾病和癌症等疾病的发生。这些干扰的机制表明，细胞外微环境和细胞功能之间存在着复杂的相互作用。此外，细胞外基质的改变也会导致张力平衡的持续破坏，使细胞外基质成为一种基于力学的记忆存储装置，从而使疾病持续存在或恢复正常组织行为。
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