Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco (UCSF), CA, USA.
Nat Rev Mol Cell Biol. 2011 May;12(5):308-19. doi: 10.1038/nrm3112.
All cells exist within the context of a three-dimensional microenvironment in which they are exposed to mechanical and physical cues. These cues can be disrupted through perturbations to mechanotransduction, from the nanoscale-level to the tissue-level, which compromises tensional homeostasis to promote pathologies such as cardiovascular disease and cancer. The mechanisms of such perturbations suggest that a complex interplay exists between the extracellular microenvironment and cellular function. Furthermore, sustained disruptions in tensional homeostasis can be caused by alterations in the extracellular matrix, allowing it to serve as a mechanically based memory-storage device that can perpetuate a disease or restore normal tissue behaviour.
所有细胞都存在于三维微环境中，在这个环境中，它们会受到机械和物理线索的影响。这些线索可以通过从纳米级到组织级的机械转导的干扰而被破坏，这会破坏张力平衡，促进心血管疾病和癌症等疾病的发生。这些干扰的机制表明，细胞外微环境和细胞功能之间存在着复杂的相互作用。此外，细胞外基质的改变也会导致张力平衡的持续破坏，使细胞外基质成为一种基于力学的记忆存储装置，从而使疾病持续存在或恢复正常组织行为。
