Krause Sonja, Debus Jürgen, Neuhof Dirk
Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany.
Recent Results Cancer Res. 2011;183:285-91. doi: 10.1007/978-3-540-85772-3_13.
Solitary plasmocytoma occurring in bone (solitary plasmocytoma of the bone, SBP) or in soft tissue (extramedullary plasmocytoma, EP) can be treated effectively and with little toxicity by local radiotherapy. Ten-year local control rates of up to 90% can be achieved. Patients with multiple myeloma often suffer from symptoms such as pain or neurological impairments that are amenable to palliative radiotherapy. In a palliative setting, short treatment schedules and lower radiation doses are used to reduce toxicity and duration of hospitalization. In future, low-dose total body irradiation (TBI) may play a role in a potentially curative regimen with nonmyeloablative conditioning followed by allogenic peripheral blood stem cell transplantation.
发生于骨的孤立性浆细胞瘤（骨孤立性浆细胞瘤，SBP）或软组织的孤立性浆细胞瘤（髓外浆细胞瘤，EP），通过局部放疗可得到有效治疗，且毒性较小。十年局部控制率可达90%。多发性骨髓瘤患者常出现疼痛或神经功能障碍等症状，适合进行姑息性放疗。在姑息治疗中，采用短疗程和较低辐射剂量以降低毒性和缩短住院时间。未来，低剂量全身照射（TBI）可能在一种潜在的治愈方案中发挥作用，该方案采用非清髓性预处理，随后进行异基因外周血干细胞移植。
