Morisaki I, Mihara J, Kato K, Kitamura K, Adachi C, Sobue S, Hamada S
Clinical Unit of Dentistry for the Handicapped, Osaka University Faculty of Dentistry, Japan.
Arch Oral Biol. 1990;35(9):753-8. doi: 10.1016/0003-9969(90)90099-v.
Inbred Fischer rats were fed a high sucrose diet (No. 2000) containing phenytoin (5,5-diphenyl-hydantoin) for 52 days, which produced serum and salivary PHT levels of 13-14 and 2.6-2.7 micrograms/ml, respectively. Gingival overgrowth was induced in the molar region of all PHT-treated rats but was more severe in Streptococcus sobrinus 6715-infected rats than in non-infected rats, which had lower plaque scores. No significant overgrowth was found in rats infected with Strep. sobrinus and fed the same diet without PHT. Thus dental plaque accumulation enhanced, but was not essential for the development of the PHT-induced gingival overgrowth. Histological examination showed that the density of fibroblasts and connective tissue fibres was similar in all groups. This experimental model could serve as a useful means of understanding the pathogenesis of PHT-induced gingival overgrowth.
将近交系Fischer大鼠喂食含苯妥英（5,5 - 二苯基乙内酰脲）的高蔗糖饮食（2000号）52天，其血清和唾液中苯妥英水平分别为13 - 14微克/毫升和2.6 - 2.7微克/毫升。所有接受苯妥英治疗的大鼠磨牙区均出现牙龈增生，但在感染远缘链球菌6715的大鼠中比未感染大鼠更严重，未感染大鼠的菌斑评分较低。在感染远缘链球菌且喂食不含苯妥英的相同饮食的大鼠中未发现明显的增生。因此，牙菌斑积聚增加，但对于苯妥英诱导的牙龈增生的发展并非必不可少。组织学检查显示，所有组中成纤维细胞和结缔组织纤维的密度相似。该实验模型可作为了解苯妥英诱导的牙龈增生发病机制的有用手段。
