雌激素治疗、大豆异黄酮及其联合治疗对去卵巢大鼠下颌下腺的影响。

Effect of estrogen therapy, soy isoflavones, and the combination therapy on the submandibular gland of ovariectomized rats.

机构信息

Department of Bioscience and Oral Diagnosis, São José dos Campos School of Dentistry, State University of São Paulo, São Paulo, Brazil.

出版信息

Pathol Res Pract. 2011 May 15;207(5):300-5. doi: 10.1016/j.prp.2011.01.002. Epub 2011 Apr 21.

DOI:10.1016/j.prp.2011.01.002

PMID:21514062

Abstract

The objective of this study was to evaluate the effect of estrogen deficiency, estrogen therapy, and soy isoflavones on the salivary glands in female rats. Ninety-six animals were ovariectomized, and 24 were sham-operated. Among the ovariectomized rats, 24 received 17β-estradiol; 24 received isoflavone extract; 24 received a combination therapy of both; and 24 received water as placebo. The submandibular glands were histomorphometrically analyzed. As a result, the ANOVA test revealed that the hormonal deficiency affected the acini and the ducts of ovariectomized rats, reducing their percentage compared to the sham group. All treatments caused an increase in ducts and acini compared to the placebo group. It was concluded that the estrogen deficiency may be related to salivary gland function due to a reduction in the quantity of salivary acini and ducts secondary to ovariectomy. The estrogen therapy, soy isoflavone therapy, and the combination of both are effective in reducing the effects of ovariectomy on the salivary glands.

摘要

本研究旨在评估雌激素缺乏、雌激素治疗和大豆异黄酮对雌性大鼠唾液腺的影响。96 只动物接受了卵巢切除术，24 只进行了假手术。在卵巢切除的大鼠中，24 只接受了 17β-雌二醇治疗；24 只接受了异黄酮提取物治疗；24 只接受了两者的联合治疗；24 只接受了水作为安慰剂。对颌下腺进行了组织形态计量学分析。结果表明，激素缺乏会影响卵巢切除术大鼠的腺泡和导管，使其百分比与假手术组相比降低。与安慰剂组相比，所有治疗方法均导致导管和腺泡增加。结论认为，雌激素缺乏可能与唾液腺功能有关，因为卵巢切除术导致唾液腺腺泡和导管数量减少。雌激素治疗、大豆异黄酮治疗以及两者的联合治疗均能有效减轻卵巢切除术对唾液腺的影响。