Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 624N. Broadway, Room 704, Baltimore, MD 21205, USA.
Drug Alcohol Depend. 2011 Nov 1;118(2-3):216-23. doi: 10.1016/j.drugalcdep.2011.03.027. Epub 2011 Apr 22.
We examined developmental trajectories of marijuana use among a cohort of urban African Americans followed from first grade to mid adulthood. We compared risk factors in childhood and adolescence and consequences in mid adulthood across trajectory groups.
Using semiparametric group-based mixture modeling, five marijuana trajectories for men (n=455) and four trajectories for women (n=495) were identified extending from adolescence to young adulthood (age 32). We labeled the four trajectory groups similar for men and women "abstainers," "adolescent only users," "early adulthood decliners," and "persistent users." We named the unique fifth group for men "late starters."
Multivariate multinomial logistic regressions show that childhood problem behaviors, adolescent family involvement, and dropping out of high school differentiated trajectory membership. Analyses comparing the trajectory groups on behavioral, social, and health outcomes at age 42 revealed that for both men and women, those in the persistent trajectory had the most problems, and those in the early adult decliner group also had specific problems. Male late starters also had poor outcomes.
The findings point to the value of identifying specific patterns of substance use over the life course and understanding the differences in their correlates and consequences. The implications of these findings are discussed.
我们研究了一个城市非裔美国人队列从一年级到成年中期的大麻使用发展轨迹。我们比较了儿童期和青少年期的风险因素以及成年中期的后果在轨迹组之间的差异。
使用半参数基于群组的混合建模,我们确定了男性(n=455)和女性(n=495)从青春期到成年早期(32 岁)的五个大麻轨迹。我们将男女相似的四个轨迹组标记为“不使用者”、“青少年仅使用者”、“早期成年衰退者”和“持续使用者”。我们将男性特有的第五个组命名为“晚期使用者”。
多变量多项逻辑回归显示,儿童期的行为问题、青少年期的家庭参与以及高中辍学率区分了轨迹组的成员。在 42 岁时,对轨迹组的行为、社会和健康结果进行的分析表明,对于男性和女性来说,那些处于持续轨迹的人问题最多,而那些处于早期成年衰退组的人也有特定的问题。男性晚期使用者也有不良后果。
这些发现表明,确定生命过程中特定的物质使用模式并理解其相关性和后果的差异是有价值的。讨论了这些发现的意义。