Chen Si-Ze, Chen Xue-Mei, Ding Ying, Wang Xi-Cheng, Zhang Fan, Mo Kai-Lan
epartment of Oncology, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2011 Apr;31(4):727-9.
To compare the therapeutic effect and adverse effects of two regimens, namely cisplatin and docetaxel (DC) regimen and fluorouracil (PF) regimen, both with concurrent radiotherapy, in the treatment of advanced esophageal squamous cancer.
Forty-eight patients with esophageal squamous cancer were randomly assigned in DC regimen and PF regimen groups. All the patients received conventional radiotherapy at a total dose of 60 Gy (in 30 fractions) for 6 weeks. In DC regimen group, the patients received intravenous infusion of docetaxel (75 mg/m(2)) for 1 h on day 1 and DDP (25 mg/m(2) daily) on days 1-3, with every 28 days as one cycle. PF regimen consisted of cisplatin (25 mg/m(2)) on days 1-3 and continuous intravenous infusion of fluorouracil (500 mg/m(2)) for 5 days, with every 28 days as one cycle. All the patients were suggested to have no less than 2 cycles.
The 3-year median survival time in DC regimen was slightly longer than that in PF regimen group (26 vs 23 months, Χ2=3.4041, P=0.065). The same result was also found in the short-term effect and adverse reactions including ?myelosuppression and gastrointestinal reactions. Only the adverse reaction of radiotherapy-induced esophagitis showed a significant difference between the two groups (P=0.049).
DC regimen with synchronous radiotherapy is effective and safe for treating advanced esophageal squamous cancer.
比较顺铂联合多西他赛（DC）方案和氟尿嘧啶（PF）方案同步放疗治疗晚期食管鳞状癌的疗效及不良反应。
48例食管鳞状癌患者随机分为DC方案组和PF方案组。所有患者均接受常规放疗，总剂量60 Gy（分30次），为期6周。DC方案组患者于第1天静脉滴注多西他赛（75 mg/m²）1小时，第1 - 3天静脉滴注顺铂（25 mg/m²），每28天为1个周期。PF方案由第1 - 3天静脉滴注顺铂（25 mg/m²）和持续静脉滴注氟尿嘧啶（500 mg/m²）5天组成，每28天为1个周期。所有患者均建议接受不少于2个周期的治疗。
DC方案组的3年中位生存时间略长于PF方案组（26个月对23个月，Χ² = 3.4041，P = 0.065）。在短期疗效和包括骨髓抑制及胃肠道反应在内的不良反应方面也得到了相同结果。两组之间仅放疗引起的食管炎不良反应存在显著差异（P = 0.049）。
DC方案同步放疗治疗晚期食管鳞状癌有效且安全。
