Franz C, Linss G, Franz N
Klinik für Innere Medizin Theodor Brugsch, der Humboldt-Universität zu Berlin.
Z Gesamte Inn Med. 1990 Dec 15;45(24):723-8.
The literature review reflects new aspects of pathophysiology and pathogenesis of arterial hypertension with special regard to the role of tissue renin-angiotensin-systems, endothelial and growth factors. The arteriolar wall as well as different organs produce angiotensin, which is of higher regulatory capability than the circulating angiotensin. Natriuretic hormones, endogenous opioids, neuropeptide Y and other vasoactive peptides are accepted as new humoral factors and neuromediators with different influence on the blood volume and the peripheral resistance. The vessel endothelium produces potent vasoconstricting (e.g. endothelin and vasodilating (e.g. EDRF) factors. Finally, growth factors with their potential role in vessel wall and myocardial hyperplasia/hypertrophy are analyzed. Tissue systems, endothelial and growth factors as new elements of arterial hypertension pathogenesis may influence the further development of new antihypertensive drugs.
文献综述反映了动脉高血压病理生理学和发病机制的新方面，特别关注组织肾素 - 血管紧张素系统、内皮因子和生长因子的作用。小动脉壁以及不同器官都会产生血管紧张素，其调节能力高于循环中的血管紧张素。利钠激素、内源性阿片肽、神经肽Y和其他血管活性肽被认为是新的体液因子和神经介质，它们对血容量和外周阻力有不同影响。血管内皮会产生强效血管收缩因子（如内皮素）和血管舒张因子（如内皮舒张因子）。最后，分析了生长因子在血管壁和心肌增生/肥大中的潜在作用。组织系统、内皮因子和生长因子作为动脉高血压发病机制的新要素，可能会影响新型抗高血压药物的进一步研发。
