从通道阻断角度看钾通道离子选择性的起源 - Suppr

Origins of ion selectivity in potassium channels from the perspective of channel block.

作者信息

Nimigean Crina M, Allen Toby W

机构信息

Department of Anesthesiology, Weill Medical College, Cornell University, New York, NY 10065, USA. crn2002@med.cornell.edu

出版信息

J Gen Physiol. 2011 May;137(5):405-13. doi: 10.1085/jgp.201010551.

DOI:10.1085/jgp.201010551

PMID:21518829

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3082928/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c760/3082928/0cde510bef30/JGP_201010551_RGB_Fig1.jpg

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Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore.

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Origins of ion selectivity in potassium channels from the perspective of channel block.

J Gen Physiol. 2011 May;137(5):405-13. doi: 10.1085/jgp.201010551.

A minimalist model for ion partitioning and competition in a K+ channel selectivity filter.

J Gen Physiol. 2011 Sep;138(3):371-3. doi: 10.1085/jgp.201110694.

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J Gen Physiol. 2011 May;137(5):397-403. doi: 10.1085/jgp.201010546.

Structure of potassium channels.

Cell Mol Life Sci. 2015 Oct;72(19):3677-93. doi: 10.1007/s00018-015-1948-5. Epub 2015 Jun 13.

Pore hydration states of KcsA potassium channels in membranes.

J Biol Chem. 2015 Oct 30;290(44):26765-75. doi: 10.1074/jbc.M115.661819. Epub 2015 Sep 14.

Crystallographic study of the tetrabutylammonium block to the KcsA K+ channel.

J Mol Biol. 2007 Feb 23;366(3):806-14. doi: 10.1016/j.jmb.2006.11.081. Epub 2006 Dec 2.

Keeping K+ completely comfortable.

Nat Struct Biol. 2001 Dec;8(12):1011-3. doi: 10.1038/nsb1201-1011.

Selective exclusion and selective binding both contribute to ion selectivity in KcsA, a model potassium channel.

J Biol Chem. 2017 Sep 15;292(37):15552-15560. doi: 10.1074/jbc.M117.795807. Epub 2017 Aug 4.

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Curr Opin Struct Biol. 2004 Aug;14(4):440-6. doi: 10.1016/j.sbi.2004.06.008.

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Nat Chem Biol. 2019 Apr;15(4):377-383. doi: 10.1038/s41589-019-0240-7. Epub 2019 Mar 4.

本文引用的文献

Mechanism for selectivity-inactivation coupling in KcsA potassium channels.

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5272-7. doi: 10.1073/pnas.1014186108. Epub 2011 Mar 14.

Ion selectivity of the KcsA channel: a perspective from multi-ion free energy landscapes.

J Mol Biol. 2010 Sep 3;401(5):831-42. doi: 10.1016/j.jmb.2010.07.006. Epub 2010 Jul 17.

Coordination numbers of K(+) and Na(+) Ions inside the selectivity filter of the KcsA potassium channel: insights from first principles molecular dynamics.

Biophys J. 2010 May 19;98(10):L47-9. doi: 10.1016/j.bpj.2010.01.064.

A conserved arginine near the filter of Kir1.1 controls Rb/K selectivity.

Channels (Austin). 2010 May-Jun;4(3):203-14. doi: 10.4161/chan.4.3.11982.

Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore.

Nat Struct Mol Biol. 2009 Dec;16(12):1317-24. doi: 10.1038/nsmb.1703. Epub 2009 Nov 29.

POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES.

J Gen Physiol. 1943 Sep 20;27(1):37-60. doi: 10.1085/jgp.27.1.37.

An intersubunit salt bridge near the selectivity filter stabilizes the active state of Kir1.1.

Biophys J. 2009 Aug 19;97(4):1058-66. doi: 10.1016/j.bpj.2009.05.056.

Control of voltage-gated K+ channel permeability to NMDG+ by a residue at the outer pore.

J Gen Physiol. 2009 Apr;133(4):361-74. doi: 10.1085/jgp.200810139.

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J Physiol. 1949 Mar 1;108(1):37-77. doi: 10.1113/jphysiol.1949.sp004310.

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Biophys J. 2007 Oct 15;93(8):2635-43. doi: 10.1529/biophysj.107.108167. Epub 2007 Jun 15.

Origins of ion selectivity in potassium channels from the perspective of channel block.

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