Kuznetsov V A
Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow.
Biomed Sci. 1990;1(6):631-8.
A new mathematical model, based on a hypothesis in which two types of molecular complex which differ in their processing rate are involved in ligand binding at the cell surface, is proposed for the processing of ligand-receptor complexes. The model describes the kinetics of anti-human-CD3 monoclonal antibody endocytosis, exocytosis, and degradation by both normal and malignant T lymphocytes. The rates for the individual stages of processing of these ligand-receptor complexes are evaluated.
基于一种假设提出了一种新的数学模型，该假设认为在细胞表面配体结合过程中涉及两种处理速率不同的分子复合物，用于处理配体-受体复合物。该模型描述了正常和恶性T淋巴细胞对抗人CD3单克隆抗体的内吞、外排和降解动力学。评估了这些配体-受体复合物各个处理阶段的速率。
