Chin N S, Koong P L
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur.
Med J Malaysia. 1990 Dec;45(4):325-8.
Thirty one patients were investigated for the main complaint of easy bruising. These patients had normal platelet count with no past history of immune thrombocytopenia or systemic disorders known to predispose to bruising and a negative drug history. The evaluation of these patients included clinical review (history and physical examination) plus coagulation tests consisting of bleeding time, prothrombin time, partial thromboplastin time, thrombin time, fibrinogen level, FXIII screen and platelet functions test. Seven of the paediatric patients had acquired platelet dysfunction with eosinophilia (APDE). In 17 (94.4%) of the 18 adult patients no abnormality was demonstrated. Hence APDE was the commonest cause of easy bruising in children while the haemostatic defect contributing to easy bruising in adults remained unknown.
对31例以易出现瘀斑为主诉的患者进行了调查。这些患者血小板计数正常,既往无免疫性血小板减少症病史或已知易导致瘀斑的全身性疾病史,且药物史阴性。对这些患者的评估包括临床检查(病史和体格检查)以及凝血试验,凝血试验包括出血时间、凝血酶原时间、部分凝血活酶时间、凝血酶时间、纤维蛋白原水平、FXIII筛查和血小板功能试验。7例儿科患者患有获得性血小板功能障碍伴嗜酸性粒细胞增多症(APDE)。18例成年患者中有17例(94.4%)未发现异常。因此,APDE是儿童易出现瘀斑的最常见原因,而导致成人易出现瘀斑的止血缺陷仍不清楚。