Department of Paediatric Endocrinology, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands.
Clin Endocrinol (Oxf). 2011 Jun;74(6):732-5. doi: 10.1111/j.1365-2265.2011.03986.x.
The number of CAG repeats within the CAG repeat polymorphism of the androgen receptor (AR) gene correlates inversely with the transactivation of the receptor. We investigated the relationship between the AR CAG repeat polymorphism and longitudinal growth, puberty and body composition from prepuberty until young adult age.
Observational study with repeated measurements.
Two comparable young Dutch cohorts. The first cohort consisted of 226 subjects. Measurements were performed from 13 until 36 years of age. The second cohort consisted of 244 subjects. Measurements in this cohort were performed from 8 until 14 years of age.
Associations between height, height velocity, weight, BMI, fat mass, fat-free mass and pubertal development and CAG repeat length were measured.
Height-standard deviation scores (SDS) were inversely associated with AR CAG repeat length in boys at young, prepubertal and early pubertal age. This association diminishes in the following years and completely disappears after the age of 16 years. No associations were found with pubertal stage or any of the other parameters for body composition.
AR CAG repeat length is inversely associated with longitudinal height in young boys, before the onset of puberty. During puberty, these differences disappear, possibly overruled by a strongly developing hypothalamic-pituitary-gonadal axis.
雄激素受体（AR）基因 CAG 重复多态性中的 CAG 重复数与受体的反式激活呈负相关。我们研究了 AR CAG 重复多态性与从青春期前到成年早期的纵向生长、青春期和身体成分之间的关系。
具有重复测量的观察性研究。
两个可比的荷兰年轻队列。第一队列由 226 名受试者组成。测量从 13 岁到 36 岁进行。第二队列由 244 名受试者组成。该队列的测量从 8 岁到 14 岁进行。
测量身高、身高增长率、体重、BMI、脂肪量、去脂体重和青春期发育与 CAG 重复长度之间的关系。
在年轻、青春期前和早期青春期的男孩中，身高标准差评分（SDS）与 AR CAG 重复长度呈负相关。这种相关性在随后的几年中减弱，在 16 岁后完全消失。与青春期阶段或身体成分的任何其他参数均无关联。
在青春期前，AR CAG 重复长度与年轻男孩的纵向身高呈负相关。在青春期，这些差异消失，可能被强烈发育的下丘脑-垂体-性腺轴所取代。
