血清促甲状腺激素与体重指标的关系：来自挪威 HUNT 研究的纵向数据。

Serum TSH related to measures of body mass: longitudinal data from the HUNT Study, Norway.

机构信息

Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

出版信息

Clin Endocrinol (Oxf). 2011 Jun;74(6):769-75. doi: 10.1111/j.1365-2265.2011.04009.x.

DOI:10.1111/j.1365-2265.2011.04009.x

PMID:21521278

Abstract

OBJECTIVE

Thyroid function and body mass are related, but the causal relationship remains unclear. Our objective was to investigate the longitudinal relationship between thyroid stimulating hormone (TSH) and body mass measures [body weight, body mass index (BMI), waist circumference (WC) and waist-hip-ratio (WHR)].

DESIGN

We used data from two waves of a population-based study: HUNT 2 (1995-1997) and 3 (2006-2008). Average follow-up time was 10·5 years. Multivariable general linear and logistic regression models were used to assess the relation between TSH and the body mass measures.

PARTICIPANTS

In total 9954 women and 5066 men without self-reported thyroid disease and TSH within the reference range (0·5-3·5 mU/l) at baseline and <10 mU/l at follow-up.

RESULTS

For each mU/l increase in TSH among women, weight increased 0·9 kg (95% CI 0·8, 1·1), BMI 0·3 kg/m(2) (95% CI 0·3, 0·4) and WC 0·6 cm (95% CI 0·3, 0·8). In men, the corresponding figures were 0·8 kg (95% CI 0·5, 1·0), 0·2 kg/m(2) (95% CI 0·2, 0·3) and 0·5 cm (95% CI 0·2, 0·8). In line with this, a weight gain of more than 5 kg was associated with a TSH increase of 0·08 mU/l (95% CI 0·06, 0·11) in women and 0·15 mU/l (95% CI 0·12, 0·18) in men. Women who lost more than 5 kg decreased their TSH by 0·12 mU/l (95% CI 0·09, 0·16) and men by 0·03 mU/l (95% CI -0.02, 0·09).

CONCLUSION

Weight gain is accompanied by increasing TSH, and weight loss in women is related to decreasing TSH.

摘要

目的

甲状腺功能与体重相关，但两者之间的因果关系尚不清楚。本研究旨在探究促甲状腺激素（TSH）与体重测量值[体重、体重指数（BMI）、腰围（WC）和腰臀比（WHR）]之间的纵向关系。

设计

我们使用了一项基于人群的研究的两波数据：HUNT2（1995-1997 年）和 3（2006-2008 年）。平均随访时间为 10.5 年。采用多变量一般线性和逻辑回归模型来评估 TSH 与体重测量值之间的关系。

参与者

共有 9954 名女性和 5066 名男性，他们在基线时没有自身报告的甲状腺疾病且 TSH 处于参考范围（0.5-3.5mU/l）内，随访时 TSH<10mU/l。

结果

女性中 TSH 每增加 1mU/l，体重增加 0.9kg（95%CI0.8，1.1），BMI 增加 0.3kg/m²（95%CI0.3，0.4），WC 增加 0.6cm（95%CI0.3，0.8）。男性的相应数据分别为 0.8kg（95%CI0.5，1.0）、0.2kg/m²（95%CI0.2，0.3）和 0.5cm（95%CI0.2，0.8）。同样，体重增加超过 5kg 与女性 TSH 增加 0.08mU/l（95%CI0.06，0.11）和男性 TSH 增加 0.15mU/l（95%CI0.12，0.18）相关。体重减轻超过 5kg 的女性 TSH 降低 0.12mU/l（95%CI0.09，0.16），男性降低 0.03mU/l（95%CI-0.02，0.09）。