USDA-ARS, Forage-Animal Production Research Unit, Lexington, KY 40546, USA.
J Anim Sci. 2011 May;89(5):1603-26. doi: 10.2527/jas.2010-3478.
After a brief history of ergot alkaloids and ergotism, this review focuses on the metabolism and mechanisms of action of the ergot alkaloids. The authors provide models of how these alkaloids afflict grazing livestock under complex animal-plant/endophyte-environmental interactions. Alkaloid chemistry is presented to orient the reader to the structure-function relationships that are known to exist. Where appropriate, the medical literature is used to aid interpretation of livestock research and to provide insight into potential modes of action and alkaloid metabolism where these are not known for livestock. In closing the paper, we discuss management of ergot alkaloid intoxication in livestock and future research needs for this field of study.
在简要介绍麦角生物碱和麦角中毒的历史之后，本篇综述集中讨论了麦角生物碱的代谢和作用机制。作者提供了这些生物碱在复杂的动植物/内生菌-环境相互作用下影响放牧牲畜的模型。呈现麦角生物碱化学结构，使读者了解已知存在的结构-功能关系。在适当的情况下，引用医学文献来帮助解释家畜研究，并提供对潜在作用模式和家畜未知的生物碱代谢的深入了解。在本文的结尾，我们讨论了家畜麦角生物碱中毒的管理以及该研究领域未来的研究需求。
