Department of Otolaryngology, E-DA Hospital, I-Shou University, Kaohsiung, Taiwan, ROC.
Otolaryngol Head Neck Surg. 2011 Nov;145(5):742-7. doi: 10.1177/0194599811406064. Epub 2011 Apr 26.
Descending necrotizing mediastinitis (DNM) is a serious form of mediastinitis with a high mortality rate. It is caused by the downward spread of an oropharyngeal or cervicofascial infection. The optimal surgical approach for this often fatal disease is controversial. This article describes the authors' experience and characterizes the surgical strategies and treatment outcomes of patients with DNM.
Case series with chart review.
A tertiary referral medical center.
This study conducted a retrospective chart review of patients with deep neck infections treated at a medical center from 1994 to 2007 and identified 29 patients with DNM. The clinical characteristics and outcomes were compared between patients treated with transcervical drainage alone (group I) and those with both cervical and thoracic drainage (group II).
There were 20 patients in group I and 9 patients in group II. The overall mortality rate was 10.3%. The mean duration of the hospital stay was 29.3 ± 15.5 days. There was no statistically significant difference in age, sex distribution, or duration from the appearance of symptoms to hospital admission between the 2 groups. The duration of hospital stay, tracheotomy rate, and mortality rate also did not differ significantly between the 2 groups. However, the numbers of surgeries were significantly higher in group II than in group I.
Transthoracic mediastinal drainage is not a compulsory therapy, but timely, aggressive, transcervical mediastinal drainage with extensive debridement is very important for a good outcome when treating DNM patients.
下行性坏死性纵隔炎(DNM)是一种严重的纵隔炎,死亡率很高。它是由咽或颈筋膜感染向下扩散引起的。对于这种常致命的疾病,最佳的手术方法存在争议。本文描述了作者的经验,并对 DNM 患者的手术策略和治疗结果进行了特征描述。
病例系列和图表回顾。
三级转诊医疗中心。
本研究对 1994 年至 2007 年在医疗中心治疗的深部颈部感染患者进行了回顾性图表回顾,并确定了 29 例 DNM 患者。比较了仅行颈内引流(I 组)和颈内及胸内引流(II 组)治疗的患者的临床特征和结果。
I 组有 20 例患者,II 组有 9 例患者。总死亡率为 10.3%。平均住院时间为 29.3±15.5 天。两组间年龄、性别分布或从症状出现到住院的时间均无统计学差异。两组间住院时间、气管切开率和死亡率也无显著差异。然而,II 组的手术次数明显多于 I 组。
经胸纵隔引流不是强制性治疗,但及时、积极的经颈纵隔引流并广泛清创对 DNM 患者的良好预后非常重要。