Mazzella Antonio, Santagata Mario, Cecere Atirge, La Mart Ettore, Fiorelli Alfonso, Tartaro Gianpaolo, Tafuri Domenico, Testa Domenico, Grella Edoardo, Perrotta Fabio, Bianco Andrea, Mazzarella Gennaro, Santini Mario
Thoracic Surgery Unit, Second University of Naples, Italy.
Maxillo-Facial Surgery Unit, Second University of Naples, Italy.
Open Med (Wars). 2016 Nov 19;11(1):449-460. doi: 10.1515/med-2016-0080. eCollection 2016.
Descending Necrotizing Mediastinitis (DNM) is a polymicrobic, dangerous and often fatal process, arising from head or neck infections and spreading along the deep fascial cervical planes, descending into the mediastinum. It can rapidly progress to sepsis and can frequently lead to death. It has a high mortality rate, up to 40% in the different series, as described in the literature. Surgical and therapeutic management has been discussed for long time especially in an elderly patient population. The literature has been reviewed in order to evaluate different pathogenesis and evolution and to recognise a correct therapeutic management.
下行性坏死性纵隔炎（DNM）是一种由多种微生物引起的、危险且常致命的病症，源于头颈部感染，沿颈部深筋膜平面蔓延，下行至纵隔。它可迅速发展为脓毒症，且常导致死亡。如文献所述，其死亡率很高，在不同系列研究中可达40%。长期以来一直在讨论手术及治疗管理问题，尤其是针对老年患者群体。为评估不同的发病机制和演变过程并确定正确的治疗管理方法，对相关文献进行了综述。
