一种使用电控按需形成和合并微滴的微流控平台。
A microfluidic platform for on-demand formation and merging of microdroplets using electric control.
机构信息
Physics of Complex Fluids, Faculty of Science and Technology, IMPACT and MESA+ Institutes, University of Twente, P.O. Box 217, 7500AE Enschede, The Netherlands.
出版信息
Biomicrofluidics. 2011 Mar 31;5(1):11101. doi: 10.1063/1.3570666.
Abstract
We discuss a microfluidic system in which (programmable) local electric fields originating from embedded and protected electrodes are used to control the formation and merging of droplets in a microchannel. The creation of droplets-on-demand (DOD) is implemented using the principle of electrowetting. Combined with hydrodynamic control, the droplet size and formation frequency can be varied independently. Using two synchronized DOD injectors, merging-on-demand (MOD) is achieved via electrocoalescence. The efficiency of MOD is 98% based on hundreds of observations. These two functionalities can be activated independently.
摘要
我们讨论了一种微流控系统，其中（可编程）局部电场源自嵌入式和受保护的电极，用于控制微通道中液滴的形成和合并。按需形成液滴（DOD）是通过电润湿原理实现的。与流体动力学控制相结合，可独立改变液滴尺寸和形成频率。使用两个同步的 DOD 注射器，通过电融合实现按需合并（MOD）。基于数百次观察，MOD 的效率为 98%。这两个功能可以独立激活。
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本文引用的文献
1
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Langmuir. 2010 Sep 21;26(18):14443-9. doi: 10.1021/la101517t.
2
High-throughput automated droplet microfluidic system for screening of reaction conditions.
Lab Chip. 2010 Apr 7;10(7):816-8. doi: 10.1039/b925500a. Epub 2010 Feb 16.
3
Electrically initiated upstream coalescence cascade of droplets in a microfluidic flow.
Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Oct;80(4 Pt 2):046303. doi: 10.1103/PhysRevE.80.046303. Epub 2009 Oct 2.
4
Electro-coalescence of digitally controlled droplets.
Anal Chem. 2009 Sep 1;81(17):7321-5. doi: 10.1021/ac901188n.
5
A fast and efficient microfluidic system for highly selective one-to-one droplet fusion.
Lab Chip. 2009 Sep 21;9(18):2665-72. doi: 10.1039/b903608c. Epub 2009 Jun 12.
6
On-chip electrocoalescence of microdroplets as a function of voltage, frequency and droplet size.
Lab Chip. 2009 Sep 21;9(18):2652-8. doi: 10.1039/b906298j. Epub 2009 Jun 10.
7
Breaking of an emulsion under an ac electric field.
Phys Rev Lett. 2009 May 8;102(18):188304. doi: 10.1103/PhysRevLett.102.188304. Epub 2009 May 7.
8
Microvalve-actuated precise control of individual droplets in microfluidic devices.
Lab Chip. 2009 May 21;9(10):1340-3. doi: 10.1039/b821803j. Epub 2009 Mar 27.
9
Efficient on-demand compound droplet formation: from microfluidics to microdroplets as miniaturized laboratories.
Small. 2009 May;5(10):1149-52. doi: 10.1002/smll.200801598.
10
An unsteady microfluidic T-form mixer perturbed by hydrodynamic pressure.
J Micromech Microeng. 2008 Mar 6;18:45015. doi: 10.1088/0960-1317/18/4/045015.
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