2009 年 12 月至 2010 年 5 月期间，波斯尼亚和黑塞哥维那联邦爆发风疹疫情，表明在战争期间（1992-1995 年）未能进行疫苗接种。

An outbreak of rubella in the Federation of Bosnia and Herzegovina between December 2009 and May 2010 indicates failure to vaccinate during wartime (1992-1995).

机构信息

Institute of Clinical Microbiology, Clinical Centre University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

出版信息

Epidemiol Infect. 2012 Mar;140(3):447-53. doi: 10.1017/S0950268811000707. Epub 2011 Apr 28.

Abstract

A rubella outbreak involving 1900 cases was recorded in the Federation of Bosnia and Herzegovina between mid-December 2009 and the end of May 2010. Sera from 389 suspected rubella cases were examined for the presence of rubella-specific IgM and IgG antibodies. A total of 32 throat swabs from suspected rubella cases were tested by RT-PCR and were used to attempt virus isolation. Most patients (945/1900, 49·73%) had never received rubella vaccination or had an unknown vaccination status (563/1900, 29·63%). About 45% (178/389) of suspected rubella patients were IgM positive. From 13 of the throat swabs a virus isolate and E1 gene sequences attributed to genotype 2B were obtained. The rubella outbreak was due to failure to vaccinate during the war period (1992-1995) and emphasizes the need for additional vaccination opportunities.

摘要

2009 年 12 月中旬至 2010 年 5 月底，波斯尼亚和黑塞哥维那联邦记录了一起涉及 1900 例风疹病例的暴发。对 389 例疑似风疹病例的血清进行了风疹特异性 IgM 和 IgG 抗体检测。对 32 份疑似风疹病例的咽拭子进行了 RT-PCR 检测，并尝试进行病毒分离。大多数患者（1900 例中的 945 例，49.73%）从未接种过风疹疫苗或疫苗接种情况未知（1900 例中的 563 例，29.63%）。约 45%（178/389）的疑似风疹患者 IgM 阳性。从 13 份咽拭子中获得了与基因型 2B 相关的病毒分离株和 E1 基因序列。此次风疹暴发是由于在战争期间（1992-1995 年）未能接种疫苗所致，这强调了需要提供更多的接种机会。