哌醋甲酯治疗未控制癫痫发作的儿童和青少年注意缺陷多动障碍症状的疗效和安全性：巴西样本研究和文献综述。
Efficacy and safety of methylphenidate in treating ADHD symptoms in children and adolescents with uncontrolled seizures: a Brazilian sample study and literature review.
机构信息
Faculty of Medicine of the University of Joinville, Clinica Neurologica, Joinville, SC, Brazil.
出版信息
Epilepsy Behav. 2011 Jul;21(3):228-32. doi: 10.1016/j.yebeh.2011.02.029. Epub 2011 Apr 27.
OBJECTIVE
Attention-deficit/hyperactivity disorder (ADHD) is observed in 30% of children and adolescents with epilepsy. Recent studies have demonstrated the safety of methylphenidate (MPH) in patients with controlled epilepsy. There are few studies of patients with uncontrolled epilepsy. The goal was to study the efficacy and safety of MPH use in children and adolescents diagnosed with ADHD and uncontrolled epilepsy.
METHODS
We evaluated 24 patients ranging from 7 to 16 years of age who took MPH for 6 months. Inclusion criteria were at least two epileptic seizures in the previous 6 months and a diagnosis of ADHD based on DSM-IV criteria.
CONCLUSION
Patients were classified according to ADHD subtype as follows: 41.7% inattentive type, 37.5% combined, and 20.8% hyperactive/impulsive type; 58.3% had partial epilepsy and 41.7% generalized epilepsy. There was an overall improvement in ADHD symptoms in 70.8% of patients, and there was no increase in frequency of epileptic seizures in 22 patients (91.6%).
目的
注意缺陷多动障碍（ADHD）在 30%的癫痫儿童和青少年中被观察到。最近的研究表明，哌醋甲酯（MPH）在癫痫得到控制的患者中是安全的。但对未得到控制的癫痫患者的研究较少。本研究旨在研究在诊断为 ADHD 且癫痫未得到控制的儿童和青少年中使用 MPH 的疗效和安全性。
方法
我们评估了 24 名年龄在 7 至 16 岁之间的患者，他们服用 MPH 治疗了 6 个月。纳入标准为过去 6 个月内至少有两次癫痫发作，且根据 DSM-IV 标准诊断为 ADHD。
结论
根据 ADHD 亚型对患者进行分类如下：41.7%为注意力不集中型，37.5%为混合型，20.8%为多动/冲动型；58.3%为部分性癫痫，41.7%为全面性癫痫。70.8%的患者 ADHD 症状总体改善，22 名患者（91.6%）癫痫发作频率无增加。
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