跑步机跑步对链脲佐菌素诱导的糖尿病大鼠齿状回谷氨酸和γ-氨基丁酸细胞外基础水平的影响。
Effects of treadmill running on extracellular basal levels of glutamate and GABA at dentate gyrus of streptozotocin-induced diabetic rats.
作者信息
Reisi Parham, Alaei Hojjatallah, Babri Shirin, Sharifi Mohammad Reza, Mohaddes Gisue, Soleimannejad Elaheh, Rashidi Bahman
机构信息
Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
J Res Med Sci. 2010 May;15(3):172-4.
BACKGROUND
The present study evaluated the effects of treadmill running on extracellular basal levels of glutamate and GABA at dentate gyrus of streptozotocin-induced diabetic rats.
METHODS
After 12 weeks of diabetes induction and exercise period, extracellular levels of glutamate and GABA were investigated.
RESULTS
The results showed that glutamate levels were significantly decreased in diabetes-rest group comparing to the control-rest and the diabetes-exercise groups.
CONCLUSIONS
The findings support the possibility that treadmill running is helpful in alleviating neurotransmitter homeostasis and alterations in transmission in diabetes mellitus.
背景
本研究评估了跑步机运动对链脲佐菌素诱导的糖尿病大鼠齿状回中谷氨酸和γ-氨基丁酸细胞外基础水平的影响。
方法
在诱导糖尿病和运动12周后，研究了谷氨酸和γ-氨基丁酸的细胞外水平。
结果
结果显示，与对照静止组和糖尿病运动组相比，糖尿病静止组的谷氨酸水平显著降低。
结论
这些发现支持了跑步机运动有助于缓解糖尿病中神经递质稳态和传递改变的可能性。
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