反复接触吗啡会改变利多卡因对大鼠的脊髓镇痛效果吗？
Can repeated exposure to morphine change the spinal analgesic effects of lidocaine in rats?
作者信息
Dabbagh Ali, Moghadam Shervin Farkhondehkish, Rajaei Samira, Mansouri Zahra, Manaheji Homa Shardi
机构信息
Associate Professor, Fellowship in Cardiac Anesthesiology, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
J Res Med Sci. 2011 Oct;16(10):1361-5.
BACKGROUND
Chronic opium exposure leads to altered response to opioid compounds. The aim of this study was to assess the behavioral effects of opium tolerance on the analgesic effects of intrathecal lidocaine in rats.
METHODS
Twenty-four adult male Sprague Dawley rats with intrathecal (IT) catheters were divided into 3 groups of 8. The first group was morphine tolerant and received IT lidocaine (ML). Rats in the second group were not morphine tolerant and received IT lidocaine (L), while the third group consisted of not morphine tolerant rats that received IT placebo. Tail flick test was done and maximal possible antinociceptive effects (MPAE) were compared using analysis of variance (ANOVA).
RESULTS
While percent of MPAE significantly increased in the L group, it had a significant reduction in the ML group (P < 0.001).
CONCLUSIONS
After intrathecal lidocaine administration, a hyperalgesic response was seen in morphine tolerant rats and an analgesic response was seen in the lidocaine group.
背景
长期接触鸦片会导致对阿片类化合物的反应改变。本研究的目的是评估鸦片耐受对大鼠鞘内注射利多卡因镇痛效果的行为学影响。
方法
将24只成年雄性Sprague Dawley大鼠植入鞘内（IT）导管，分为3组，每组8只。第一组为吗啡耐受组，接受鞘内注射利多卡因（ML）。第二组大鼠非吗啡耐受，接受鞘内注射利多卡因（L），而第三组由非吗啡耐受大鼠组成，接受鞘内注射安慰剂。进行甩尾试验，并使用方差分析（ANOVA）比较最大可能镇痛效果（MPAE）。
结果
L组的MPAE百分比显著增加，而ML组则显著降低（P < 0.001）。
结论
鞘内注射利多卡因后，吗啡耐受大鼠出现痛觉过敏反应，利多卡因组出现镇痛反应。
Zotero 插件