新诊断的精神分裂症患者及服用抗精神病药物患者体内的必需微量元素和重金属
Essential trace metals and heavy metals in newly diagnosed schizophrenic patients and those on anti-psychotic medication.
作者信息
Arinola Ganiyu, Idonije Blessing, Akinlade Kehinde, Ihenyen Olubisi
机构信息
Department of Chemical Pathology, University of Ibadan, Ibadan, Oyo State, Nigeria.
出版信息
J Res Med Sci. 2010 Sep;15(5):245-9.
BACKGROUND
Nutritional deprivation in the early stage of life increases the risk of developing schizophrenia. Oxidative stress, disturbed thinking and irrational behavior which are common to schizophrenic patients may be a result of changes in the levels of certain trace metals.
METHODS
Twenty (20) healthy volunteers and a total of thirty-five (35) schizophrenic patients consisting of 20 on antipsychotic drugs for at least 2 weeks and 15 newly diagnosed but not taking antipsychotic drugs were considered. The plasma levels of trace metals were analyzed using atomic absorption spectrophotometer.
RESULTS
Fe and Se were significantly reduced in newly diagnosed and medicated-schizophrenic patients compared with controls. Pb, Cd and Cr were significantly raised in newly diagnosed drug free schizophrenic patients compared with controls. While Cr and Cd were significantly raised in schizophrenic patients on treatment compared with the controls.
CONCLUSIONS
Levels of certain nutritionally essential trace metals (Fe and Se) were reduced while levels of certain heavy metals (Pb, Cr and Cd) were raised in schizophrenic patients.
背景
生命早期的营养缺乏会增加患精神分裂症的风险。精神分裂症患者常见的氧化应激、思维紊乱和非理性行为可能是某些微量元素水平变化的结果。
方法
研究纳入了20名健康志愿者以及总共35名精神分裂症患者，其中20名服用抗精神病药物至少2周，15名新诊断但未服用抗精神病药物。使用原子吸收分光光度计分析血浆中微量元素的水平。
结果
与对照组相比，新诊断和服用药物的精神分裂症患者的铁和硒显著降低。与对照组相比，新诊断未服药的精神分裂症患者的铅、镉和铬显著升高。与对照组相比，接受治疗的精神分裂症患者的铬和镉显著升高。
结论
精神分裂症患者体内某些营养必需微量元素（铁和硒）水平降低，而某些重金属（铅、铬和镉）水平升高。
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