囊外侵犯是结直肠癌疾病复发的一个危险因素。
Extracapsular invasion as a risk factor for disease recurrence in colorectal cancer.
机构信息
Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma 371-8511, Japan.
出版信息
World J Gastroenterol. 2011 Apr 21;17(15):2003-6. doi: 10.3748/wjg.v17.i15.2003.
Abstract
AIM
To evaluate the presence of extracapsular invasion (ECI) in positive nodes as a predictor of disease recurrence disease in colorectal cancer.
METHODS
Two hundred and twenty-eight consecutive patients who underwent colorectal resection were identified for inclusion in this study, of which 46 had positive lymph nodes. Among 46 cases with stage IIIcolorectal cancer, 16 had ECI at positive nodes and 8 had disease recurrence. The clinical and pathological features of these cases were reviewed.
RESULTS
In the univariate analysis, the number of positive lymph nodes and depth of tumor invasion were significantly associated with the presence of ECI at positive nodes. Multivariate analysis demonstrated that only ECI was a predictor of recurrence. The recurrence-free interval differed significantly among patients with ECI at positive nodes.
CONCLUSION
Our results suggest that ECI at metastatic nodes can identify which cases are at high risk of short-term disease recurrence in colorectal cancer.
摘要
目的
评估阳性淋巴结中是否存在囊外侵犯（ECI）作为结直肠癌疾病复发的预测指标。
方法
本研究纳入了 228 例连续接受结直肠切除术的患者，其中 46 例淋巴结阳性。在 46 例 III 期结直肠癌患者中，16 例阳性淋巴结存在 ECI，8 例发生疾病复发。回顾这些病例的临床和病理特征。
结果
单因素分析显示，阳性淋巴结数量和肿瘤侵犯深度与阳性淋巴结中 ECI 的存在显著相关。多因素分析表明，只有 ECI 是复发的预测因素。阳性淋巴结存在 ECI 的患者的无复发生存期差异显著。
结论
我们的研究结果表明，转移淋巴结中的 ECI 可以识别结直肠癌中短期疾病复发风险较高的病例。
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