卵巢癌中肿瘤组织学、类固醇受体状态与腺苷脱氨酶复合蛋白免疫反应性之间的相关性

Correlation between tumor histology, steroid receptor status, and adenosine deaminase complexing protein immunoreactivity in ovarian cancer.

作者信息

Rao B R, Slotman B J, Geldof A A, Dinjens W N

机构信息

Department of Endocrinology, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands.

出版信息

Int J Gynecol Pathol. 1990;9(1):47-54. doi: 10.1097/00004347-199001000-00004.

DOI:10.1097/00004347-199001000-00004

PMID:2152891

Abstract

Adenosine deaminase complexing protein (ADCP) immunoreactivity was investigated in 40 ovarian tumors and correlated with clinicopathologic parameters, including tumor steroid receptor content. Ten (29%) of 34 common epithelial ovarian carcinomas showed ADCP reactivity. Reactivity for ADCP was seen more frequently in mucinous (100%; p less than 0.001), well-differentiated (73%; p less than 0.001) and Stage I (56%; p less than 0.05) ovarian carcinomas. Furthermore, tumors that contained high levels of androgen receptors and tumors that did not contain estrogen receptors were more frequently ADCP positive (p less than 0.05). However, after stratifying for histologic grade, no correlation between ADCP reactivity and receptor status was found. Determination of ADCP reactivity appears to be of limited value in ovarian cancer.

摘要

对40例卵巢肿瘤进行了腺苷脱氨酶复合蛋白（ADCP）免疫反应性研究，并将其与临床病理参数相关联，包括肿瘤类固醇受体含量。34例常见上皮性卵巢癌中有10例（29%）显示ADCP反应性。ADCP反应性在黏液性卵巢癌（100%；p<0.001）、高分化卵巢癌（73%；p<0.001）和I期卵巢癌（56%；p<0.05）中更常见。此外，雄激素受体水平高的肿瘤和不含雌激素受体的肿瘤更常为ADCP阳性（p<0.05）。然而，在按组织学分级分层后，未发现ADCP反应性与受体状态之间存在相关性。ADCP反应性的测定在卵巢癌中的价值似乎有限。