Wargotz E S, Norris H J
Department of Breast and Gynecologic Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000.
Cancer. 1990 Jan 15;65(2):272-6. doi: 10.1002/1097-0142(19900115)65:2<272::aid-cncr2820650215>3.0.co;2-6.
The clinical and pathologic features of 22 examples of pure ductal squamous cell carcinoma (SqCC) of the breast are reported. All patients were women with a mean age of 53 years. Only two of the 19 women with axillary dissection had metastases, but one woman had a positive supraclavicular lymph node in the presence of negative axillary nodes. All metastases were squamous carcinoma. All patients were eligible for a minimum of 5 years' follow-up; the cumulative 5-year disease-specific survival rate was 63%. Eight women developed metastases and one also developed local recurrence, all within 2 years, and all eight died from tumor within 4 years of initial therapy (mean, 2 years). Prophylactic postoperative radiation therapy and radiation for lymph node metastases at initial surgery did not prolong survival as four of the five recipients died from tumor. Although there were no statistically significant gross or histologic differences between recurrent and nonrecurrent neoplasms, larger neoplasms tended to metastasize. Immunohistochemical study for S-100 protein identified an immunoreactive cell component in five of seven neoplasms tested. This and light microscopic findings suggest myoepithelial proliferation, differentiation, or origin.
报告了22例乳腺单纯导管鳞状细胞癌（SqCC）的临床和病理特征。所有患者均为女性，平均年龄53岁。19例行腋窝清扫术的女性中只有2例发生转移，但有1名女性在腋窝淋巴结阴性的情况下出现锁骨上淋巴结阳性。所有转移灶均为鳞状细胞癌。所有患者均至少随访5年；5年累积疾病特异性生存率为63%。8名女性发生转移，1名还出现局部复发，均在2年内发生，且所有8名患者在初始治疗后4年内死于肿瘤（平均2年）。预防性术后放疗以及初始手术时对淋巴结转移灶的放疗均未延长生存期，因为5名接受放疗的患者中有4名死于肿瘤。尽管复发肿瘤与未复发肿瘤之间在大体或组织学上无统计学显著差异，但较大的肿瘤更易发生转移。对7例肿瘤进行的S-100蛋白免疫组化研究显示，其中5例存在免疫反应性细胞成分。这一结果以及光镜检查结果提示肌上皮细胞增殖、分化或起源。
