Allary J, Weil G, Bourgain J-L
Service d'anesthésie, institut Gustave-Roussy, 114, rue Édouard-Vaillant, 94805 Villejuif, France.
Ann Fr Anesth Reanim. 2011 Jul-Aug;30(7-8):538-45. doi: 10.1016/j.annfar.2011.03.009. Epub 2011 Apr 29.
Control of residual muscle paralysis and hypothermia reduce postoperative complications rate. Short context sensitive half life anaesthetic agents allow a better adjustment of anaesthesia depth according to surgical requirement and a safe early extubation. Using a large clinical database, impact of these three strategies was assessed on clinical criteria such as use of neostigmine in postanaesthesia care unit (PACU), temperature, sedation score at the arrival into PACU and mechanical ventilation weaning.
This is a retrospective study on two separated periods. Since 2001, clinical events are entered into the database during and after anaesthesia in the same file. Agreement of anaesthesia staff to these strategies was assessed by the proportion of patients receiving modern anaesthetic agents (desflurane, sevoflurane and remifentanil) and the use of warming devices. Clinical impact was assessed by the number of patients receiving neostigmine in PACU, sedation score and temperature at the arrival in PACU and number of patients with mechanical ventilation in PACU.
Between the two periods (12,033 and 11,805 patients, respectively), use of sevoflurane, desflurane and remifentanil markedly increased, as well as the use of warming devices. Number of patients with neuromuscular reversal in PACU decreased from 73 to 11 and sedation score improved dramatically. Incidence of postoperative ventilation in PACU decreased from 1.1% (n=132) to 0.2% (n=30). Incidence of postoperative hypothermia was not changed during the two periods but incidence of hypothermia in the mechanically ventilated patient increased from 34.1 to 46.6%. Length of stay in PACU decreased from 122 to 114 minutes (p<0.05).
Implementation of new intraoperative protocols induced major effects on postoperative clinical parameters and especially postoperative mechanical ventilation. Failure of our hypothermia prevention associated with a fast return of consciousness lead to wean from mechanical ventilation hypothermic patients. Risks of this strategy were not estimated.
控制残余肌松和体温过低可降低术后并发症发生率。短效的、具有情境敏感性半衰期的麻醉药物能够根据手术需求更好地调整麻醉深度,并实现安全的早期拔管。利用一个大型临床数据库,评估了这三种策略对诸如在麻醉后恢复室(PACU)使用新斯的明、体温、进入PACU时的镇静评分以及机械通气撤机等临床指标的影响。
这是一项针对两个不同时期的回顾性研究。自2001年起,临床事件在麻醉期间及之后被录入同一文件的数据库中。通过接受现代麻醉药物(地氟烷、七氟烷和瑞芬太尼)的患者比例以及保暖设备的使用情况来评估麻醉工作人员对这些策略的认同度。通过在PACU接受新斯的明治疗的患者数量、进入PACU时的镇静评分和体温以及在PACU接受机械通气的患者数量来评估临床影响。
在这两个时期(分别为12033例和11805例患者)之间,七氟烷、地氟烷和瑞芬太尼的使用以及保暖设备的使用显著增加。在PACU接受神经肌肉逆转治疗的患者数量从73例降至11例,镇静评分显著改善。PACU术后通气的发生率从1.1%(n = 132)降至0.2%(n = 30)。两个时期术后体温过低的发生率没有变化,但机械通气患者的体温过低发生率从34.1%升至46.6%。PACU的住院时间从122分钟降至114分钟(p < 0.05)。
新的术中方案的实施对术后临床参数,尤其是术后机械通气产生了重大影响。我们预防体温过低的措施失败,加上意识快速恢复,导致体温过低的患者撤机。该策略的风险未作评估。