用于中子俘获治疗的多面体硼化合物与肿瘤靶向分子缀合物的合成。
Synthesis of conjugates of polyhedral boron compounds with tumor-seeking molecules for neutron capture therapy.
作者信息
Bregadze V, Semioshkin A, Sivaev I
机构信息
AN Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia.
出版信息
Appl Radiat Isot. 2011 Dec;69(12):1774-7. doi: 10.1016/j.apradiso.2011.01.043. Epub 2011 Apr 12.
Abstract
Recent achievements in design and synthesis of boronated acids, amino acids, glycerols as well as conjugates of polyhedral boron hydrides (ortho-carborane, closo-dodecaborate and cobalt bis(dicarbollide)) with natural porphyrins, carbohydrates and nucleosides are described.
摘要
本文描述了硼酸、氨基酸、甘油以及多面体硼氢化物（邻碳硼烷、闭式十二硼酸盐和钴双（二碳硼烷））与天然卟啉、碳水化合物和核苷的共轭物在设计与合成方面的最新成果。
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