1例桥本脑病：临床表现、影像学、病理学、治疗及预后
A case of Hashimoto encephalopathy: clinical manifestation, imaging, pathology, treatment, and prognosis.
作者信息
Zhao Weiqin, Li Jimei, Wang Jiawei, Guo Yanjun, Tuo Houzhen, Kang Zhimin, Jiang Bin, Wang Rui, Wang Dexin
机构信息
Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
出版信息
Neurologist. 2011 May;17(3):141-3. doi: 10.1097/NRL.0b013e3182173341.
INTRODUCTION
Hashimoto encephalopathy is a rare encephalopathy with positive antithyroid antibodies and normal thyroid function. We describe the clinical manifestations, neuroimaging, and histopathologic changes in a 52-year-old female with Hashimoto encephalopathy.
RESULTS
The neuroimaging changes are multifocal abnormalities in cortical and subcortical areas bilaterally not enhanced by gadolinium. After high doses of corticosteroid therapy, the changes rapidly disappeared with marked improvement of clinical symptoms.
CONCLUSIONS
This case shows the importance of assessment of antithyroid antibodies in patients with rapidly progressive cognitive dysfunction with/without the history of abnormality of thyroid function.
引言
桥本脑病是一种罕见的脑病，抗甲状腺抗体呈阳性，甲状腺功能正常。我们描述了一名52岁患有桥本脑病女性的临床表现、神经影像学及组织病理学变化。
结果
神经影像学改变为双侧皮质及皮质下区域的多灶性异常，钆增强扫描未见强化。大剂量皮质类固醇治疗后，这些改变迅速消失，临床症状明显改善。
结论
该病例表明，对于有/无甲状腺功能异常病史的快速进展性认知功能障碍患者，评估抗甲状腺抗体具有重要意义。
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