Division of Endocrinology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Pediatr Neurol. 2011 Sep;45(3):189-92. doi: 10.1016/j.pediatrneurol.2011.04.012.
Hashimoto's encephalopathy is diagnosed when patients exhibit features of corticosteroid-responsive encephalopathy and positive antithyroid antibodies. The relationship between antithyroid antibodies and encephalopathy is subject to considerable debate. We describe corticosteroid-responsive encephalopathy in a 14-year-old boy with positive antimicrosomal antibodies. His history included subtle neurocognitive decline. He presented with seizures. He underwent a brain biopsy before initiating treatment after his third episode. That biopsy was consistent with central nervous system vasculitis. This report is unique because, to our knowledge, it describes the first pretreatment brain biopsy of a pediatric patient who fits the criteria for Hashimoto's encephalopathy.
当患者表现出皮质类固醇反应性脑病和抗甲状腺抗体阳性的特征时，即可诊断为桥本脑病。抗甲状腺抗体与脑病之间的关系存在较大争议。我们描述了一例抗微粒体抗体阳性的 14 岁男孩的皮质类固醇反应性脑病。他的病史包括轻微的神经认知能力下降。他出现了癫痫发作。在第三次发作后开始治疗前，他接受了脑活检。该活检符合中枢神经系统血管炎。该报告是独特的，因为据我们所知，它描述了首例符合桥本脑病标准的儿科患者的治疗前脑活检。
