Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California-Los Angeles, 150 N Robertson Blvd, Beverly Hills, CA 90211, USA.
Menopause. 2011 Sep;18(9):962-6. doi: 10.1097/gme.0b013e3182104977.
The aim of this study was to compare the efficacy of the ultralow-dose estradiol vaginal ring with that of oral oxybutynin in the treatment of overactive bladder in postmenopausal women.
Postmenopausal women with an overactive bladder were recruited from the general gynecology clinic. Participants were randomized to receive either the ultralow-dose estradiol vaginal ring or oral oxybutynin for 12 weeks. The primary outcome was a decrease in the number of voids in 24 hours. The secondary outcomes were quality-of-life questionnaires, vaginal pH levels, and vaginal maturation index.
Fifty-nine women were enrolled. Thirty-one were randomized to receive oxybutynin, whereas 28 received the estradiol vaginal ring. Women who received oxybutynin had a mean decrease of 3.0 voids per day, and women who received the vaginal ring had a mean decrease of 4.5 voids per day, with no significant difference between the groups. There was a significant improvement in Urogenital Distress Inventory and Incontinence Impact Questionnaire scores in both groups, with no significant difference in improvement between the two groups.
Ultralow-dose estradiol-releasing vaginal ring and oral oxybutynin seem to be similarly effective in decreasing the number of daily voids in postmenopausal women with overactive bladder.
本研究旨在比较超低剂量雌二醇阴道环与口服奥昔布宁治疗绝经后女性膀胱过度活动症的疗效。
从普通妇科诊所招募患有膀胱过度活动症的绝经后女性。参与者被随机分配接受超低剂量雌二醇阴道环或口服奥昔布宁治疗 12 周。主要结局是 24 小时内排尿次数减少。次要结局是生活质量问卷、阴道 pH 值和阴道成熟指数。
共有 59 名女性入组。其中 31 名随机分配接受奥昔布宁治疗，28 名接受雌二醇阴道环治疗。接受奥昔布宁治疗的女性平均每天排尿次数减少 3.0 次，接受阴道环治疗的女性平均每天排尿次数减少 4.5 次，两组之间无显著差异。两组的尿生殖窘迫量表和尿失禁影响问卷评分均有显著改善，但两组之间的改善无显著差异。
超低剂量雌二醇释放阴道环和口服奥昔布宁似乎在减少绝经后女性膀胱过度活动症的每日排尿次数方面同样有效。
