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Parathyroid hormone-related peptide gene is expressed in the mammalian central nervous system.

作者信息

Weir E C, Brines M L, Ikeda K, Burtis W J, Broadus A E, Robbins R J

机构信息

Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06510.

出版信息

Proc Natl Acad Sci U S A. 1990 Jan;87(1):108-12. doi: 10.1073/pnas.87.1.108.

DOI:10.1073/pnas.87.1.108
PMID:2153281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC53209/
Abstract

A parathyroid hormone-related peptide (PTHRP) has been identified in human tumors associated with the syndrome of humoral hypercalcemia of malignancy. While parathyroid hormone (PTH) gene expression appears to be limited to the parathyroid glands, PTHRP mRNA has been identified in a variety of normal tissues. To investigate the apparent expression of the PTHRP in the central nervous system, we examined extracts of whole rat brain for PTHRP bioactivity by measuring adenylate cyclase-stimulating activity (ACSA) in a PTH-sensitive assay. Extracts consistently contained ACSA and this activity was completely inhibited by a PTHRP antiserum but was unaffected by a PTH antiserum. ACSA was found in a number of anatomic subregions of rat brain, being greatest in the cortex and telencephalon. RNase protection analysis revealed PTHRP transcripts in total RNA prepared from whole rat brain and from the same anatomic subregions. By in situ hybridization histochemistry, we found that the highest levels of PTHRP gene expression occurred in neurons of the cerebral cortex, hippocampus, and cerebellar cortex. These studies demonstrate that both PTHRP mRNA and biological activity are present in a number of regions of rat brain. The widespread expression of this peptide by multiple types of neurons suggests that the PTHRP may play a general role in neuronal physiology.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/8c46bea7765b/pnas01026-0130-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/ac5e1b90cb37/pnas01026-0129-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/9dc43d4b882e/pnas01026-0129-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/771bc9fcb781/pnas01026-0129-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/60c2e8b57c9f/pnas01026-0129-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/c7cf3c68471d/pnas01026-0130-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/bab995b38f02/pnas01026-0130-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/8b1453764ff0/pnas01026-0130-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/8c46bea7765b/pnas01026-0130-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/ac5e1b90cb37/pnas01026-0129-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/9dc43d4b882e/pnas01026-0129-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/771bc9fcb781/pnas01026-0129-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/60c2e8b57c9f/pnas01026-0129-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/c7cf3c68471d/pnas01026-0130-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/bab995b38f02/pnas01026-0130-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/8b1453764ff0/pnas01026-0130-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ca0/53209/8c46bea7765b/pnas01026-0130-d.jpg

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本文引用的文献

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J Clin Invest. 1983 Oct;72(4):1511-5. doi: 10.1172/JCI111108.
2
Identification of two distinct regulatory regions adjacent to the human beta-interferon gene.鉴定出与人类β-干扰素基因相邻的两个不同调控区域。
Cell. 1983 Oct;34(3):865-79. doi: 10.1016/0092-8674(83)90544-5.
3
Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy.
脊椎动物甲状旁腺激素受体家族及其配体的进化。
Front Endocrinol (Lausanne). 2015 Mar 10;6:28. doi: 10.3389/fendo.2015.00028. eCollection 2015.
4
Absence of PTHrP nuclear localization and carboxyl terminus sequences leads to abnormal brain development and function.缺乏甲状旁腺素相关蛋白的核定位序列和羧基末端序列会导致大脑发育和功能异常。
PLoS One. 2012;7(7):e41542. doi: 10.1371/journal.pone.0041542. Epub 2012 Jul 23.
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J Endocrinol. 2011 Nov;211(2):187-200. doi: 10.1530/JOE-10-0439. Epub 2011 Aug 31.
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Chemical modification of class II G protein-coupled receptor ligands: frontiers in the development of peptide analogs as neuroendocrine pharmacological therapies.化学修饰 II 类 G 蛋白偶联受体配体：开发作为神经内分泌药理学治疗的肽类似物的前沿。
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