CDX1 和 CDX2 在肠上皮化生、异型增生和胃癌中的表达。
CDX1 and CDX2 expression in intestinal metaplasia, dysplasia and gastric cancer.
机构信息
Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.
出版信息
J Korean Med Sci. 2011 May;26(5):647-53. doi: 10.3346/jkms.2011.26.5.647. Epub 2011 Apr 21.
Intestinal metaplasia (IM) has been regarded as a premalignant condition. However, the pathogenesis of IM is not fully understood. The aim of this study was to evaluate the role of CDX1 and CDX2 in the formation of IM and the progression to dysplasia and gastric cancer (GC). A total of 270 subjects included 90 with GC, dysplasia and age- and sex-matched controls. Real-time PCR (RT-PCR) was performed with body specimens for CDX1 and CDX2. The expression of CDX2 was significantly higher in H. pylori positive group than H. pylori negative group (P = 0.045). CDX1 and CDX2 expression increased proportional to the IM grade of the body (P < 0.001). CDX2 expression was significantly higher in incomplete type of IM than in complete type (P = 0.045). The expression of CDX1 in dysplasia group was significantly higher than in the control group (P = 0.001); in addition, CDX1 and CDX2 in cancer group was significantly higher than control group (P < 0.001, and P < 0.001, respectively). Aberrant expression of CDX1 and CDX2 correlated with H. pylori infection and grade of IM in the body. Furthermore, the results suggest that CDX1 and CDX2 play a role in the progression to GC and dysplasia.
肠上皮化生（IM）被认为是一种癌前状态。然而，IM 的发病机制尚不完全清楚。本研究旨在评估 CDX1 和 CDX2 在 IM 形成以及向异型增生和胃癌（GC）进展中的作用。共纳入 270 例受试者，包括 90 例 GC、异型增生和年龄及性别匹配的对照组。采用实时 PCR（RT-PCR）对 CDX1 和 CDX2 进行了身体标本检测。在 H. pylori 阳性组中，CDX2 的表达明显高于 H. pylori 阴性组（P = 0.045）。CDX1 和 CDX2 的表达随体部 IM 分级的增加而增加（P < 0.001）。不完全型 IM 中 CDX2 的表达明显高于完全型（P = 0.045）。在异型增生组中，CDX1 的表达明显高于对照组（P = 0.001）；此外，在癌症组中，CDX1 和 CDX2 的表达均明显高于对照组（P < 0.001 和 P < 0.001）。CDX1 和 CDX2 的异常表达与 H. pylori 感染和体部 IM 分级有关。此外，结果提示 CDX1 和 CDX2 在 GC 和异型增生的进展中发挥作用。
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