Chai Rui, Fu Chuan-gang, Wang Hao, Liu Lian-jie
Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2011 Apr;14(4):245-8.
To investigate factors associated with lymph node metastasis and prognosis in patients with T1-2 colorectal cancer.
Patients with pT1-2 colorectal cancer between January 1999 to January 2005 were included. Chi-square test and multivariable logistic analysis were performed to evaluate risk factors associated with lymph node metastasis. Survival outcomes were analyzed using Kaplan-Meier and Cox regression model.
Tumor location and depth of invasion were independent risk factors for lymph node metastasis(P<0.01 and P<0.05). Gender, age, tumor gross pattern, tumor differentiation, carcinoembryonic antigen level, and tumor diameter were not associated with lymph node metastasis. Lymph node metastasis and distant metastasis on postoperative follow-up were independent risk factors for survival(P<0.05 and P<0.01).
Factors associated with lymph node metastasis in pT1-2 colorectal cancer do not affect the survival. However, lymph node metastasis and distant metastasis are predictive for survival.
探讨T1-2期结直肠癌患者淋巴结转移及预后的相关因素。
纳入1999年1月至2005年1月期间的pT1-2期结直肠癌患者。采用卡方检验和多变量逻辑分析来评估与淋巴结转移相关的危险因素。使用Kaplan-Meier法和Cox回归模型分析生存结局。
肿瘤位置和浸润深度是淋巴结转移的独立危险因素（P<0.01和P<0.05）。性别、年龄、肿瘤大体形态、肿瘤分化程度、癌胚抗原水平和肿瘤直径与淋巴结转移无关。术后随访中的淋巴结转移和远处转移是生存的独立危险因素（P<0.05和P<0.01）。
pT1-2期结直肠癌中与淋巴结转移相关的因素不影响生存。然而，淋巴结转移和远处转移可预测生存。
