Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.
J Am Chem Soc. 2011 Jun 22;133(24):9164-7. doi: 10.1021/ja201627h. Epub 2011 May 3.
A facile and efficient enantioselective bromoaminocyclization of unsaturated sulfonamides has been developed using an amino-thiocarbamate catalyst. A range of enantioenriched pyrrolidines were prepared with up to 99% yield and 99% ee. The corresponding lactams could be obtained through oxidation of the pyrrolidines.
一种简便高效的手性氨基硫脲催化剂催化的不饱和磺酰胺的溴代氨环化反应已经被开发出来。一系列具有高达 99%产率和 99%ee 值的手性吡咯烷被制备出来。通过对吡咯烷的氧化可以得到相应的内酰胺。
