Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Goettingen, Germany.
Neurobiol Learn Mem. 2011 Jul;96(1):19-26. doi: 10.1016/j.nlm.2011.04.002. Epub 2011 Apr 22.
Learning and memory are cognitive processes that are tightly regulated. A proper genome-environment interaction is a pre-requisite for cognitive function. Epigenetic processes are central regulators of genome-environment interactions. In line with this, it has been shown that the epigenetic machinery is essential for cognitive function. With a specific focus on histone acetylation, we will discuss recent research in the field of epigenetic mechanisms of learning and memory. We will also specifically address the role of histone acetylation in age-associated memory impairment and Alzheimer's disease and ask the question why targeting the epigenome could be a suitable strategy for neuroprotection and neuroregeneration.
学习和记忆是受严格调控的认知过程。适当的基因组-环境相互作用是认知功能的前提。表观遗传过程是基因组-环境相互作用的核心调节剂。与此一致，已经表明表观遗传机制对于认知功能是必不可少的。本文特别关注组蛋白乙酰化，讨论学习和记忆的表观遗传机制领域的最新研究。我们还将特别讨论组蛋白乙酰化在与年龄相关的记忆障碍和阿尔茨海默病中的作用，并提出为什么针对表观基因组可能是神经保护和神经再生的合适策略这一问题。
